RSL3

Cat. No. IC23117

CAS. No. 1219810-16-8

Key Features and Details

Category

Inhibitor&Activator

Purity

99.53%

Formula

C23H21ClN2O5

Product Size

Online Inquiry

Product Details

Product Name

RSL3

CAS No.

1219810-16-8

Molecular Weight

440.88

Synonyms

1S,3R-RSL3

Formula

C23H21ClN2O5

Appearance

Solid

Purity

99.53%

SMILES

O=C([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC

Product Overview

Description

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

In Vitro Activity

RSL3 (0-8 μM, 72 hours) potently reduces the viability of HN3 cells, with IC50s of 0.48 µM in HN3 and 5.8 µM in HN3-rslR cells, respectively. RSL3 (0-8 μM, 24 hours) reduces the expression of GPX4 protein, increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.

In Vivo Activity

RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with trigonelline in mice bearing HN3R cells.

Storage & Handling

Storage

4 °C, sealed storage, away from moisture In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Shipping

Room temperature in continental US; may vary elsewhere.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.