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Hemin
Cat. No. IC23122
CAS. No. 16009-13-5
Key Features and Details
Category
Inhibitor&Activator
Purity
≥98.0%
Formula
C34H32ClFeN4O4
Product Details
Product Name
Hemin
CAS No.
16009-13-5
Molecular Weight
651.94
Synonyms
Hemin chloride
Formula
C34H32ClFeN4O4
Appearance
Solid
Purity
≥98.0%
SMILES
[Cl-][Fe+3]123[N-]4C5=C(CCC([O-])=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC([O-])=O)=[N]3C8=C5.[H+].[H+]
Product Overview
Description
Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer.
In Vitro Activity
Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment.
In Vivo Activity
Following the administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning.
Storage & Handling
Storage
4 °C, protect from light, stored under nitrogen
*In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light, stored under nitrogen)
Shipping
Room temperature in continental US; may vary elsewhere.
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