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α-Eleostearic Acid
Cat. No. IC23222
CAS. No. 506-23-0
Product Details
Product Name
α-Eleostearic Acid
CAS No.
506-23-0
Molecular Weight
278.43
Synonyms
cis-Eleostearic acid
Formula
C18H30O2
SMILES
CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O
Product Overview
Description
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity.
In Vitro Activity
α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma.
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells.
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E.
In Vivo Activity
α-Eleostearic acid inhibits Sodium Arsenite-induced oxidative stress, including reversal of antioxidant enzyme activity and reduction of lipid peroxidation levels.
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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