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DL-Buthionine-(S,R)-sulfoximine
Cat. No. IC23141
CAS. No. 5072-26-4
Key Features and Details
Category
Inhibitor&Activator
Purity
≥98.0%
Formula
C8H18N2O3S
Product Details
Product Name
DL-Buthionine-(S,R)-sulfoximine
CAS No.
5072-26-4
Molecular Weight
222.31
Synonyms
Buthionine sulfoximine; BSO
Formula
C8H18N2O3S
Appearance
Solid
Purity
≥98.0%
SMILES
OC(C(N)CCS(CCCC)(=N)=O)=O
Product Overview
Description
DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
In Vitro Activity
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine.
In Vivo Activity
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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