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Pifithrin-β Hydrobromide
Cat. No. IC23156
CAS. No. 511296-88-1
Key Features and Details
Category
Inhibitor&Activator
Purity
99.97%
Formula
C16H17BrN2S
Product Details
Product Name
Pifithrin-β Hydrobromide
CAS No.
511296-88-1
Molecular Weight
349.29
Synonyms
PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide
Formula
C16H17BrN2S
Appearance
Solid
Purity
99.97%
SMILES
CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1.Br
Product Overview
Description
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
In Vitro Activity
Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.
Storage & Handling
Storage
4 °C, sealed storage, away from moisture
In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)
Shipping
Room temperature in continental US; may vary elsewhere.
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