Pioglitazone Potassium

Cat. No. IC23081

CAS. No. 1266523-09-4

Key Features and Details

Category

Inhibitor&Activator

Formula

C19H19KN2O3S

Product Size

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Product Details

Product Name

Pioglitazone Potassium

CAS No.

1266523-09-4

Molecular Weight

394.53

Synonyms

U 72107 potassium

Formula

C19H19KN2O3S

SMILES

CCC1=CC=C(N=C1)CCOC2=CC=C(C=C2)CC(SC([N-]3)=O)C3=O.[K+]

Product Overview

Description

Pioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium can be used in diabetes research.

In Vitro Activity

Pioglitazone potassium (0.5 or 1 μM, 5 days) can completely prevent AGEs (advanced glycation end-products)-induced β-cell necrosis and the increase of caspase-3 thereby avoiding the impaired viability caused by AGEs in pancreatic beta cell line HIT-T15. Pioglitazone potassium (1 μM, 1 h) can stimulate insulin secretion induced by low glucose concentration and attenuate the GSSG/GSH ratio in cells cultured with AGEs.

In Vivo Activity

Pioglitazone potassium (oral gavage, 10 or 30 mg/kg, once daily, 14 days) can induce improvements in insulin resistance and diabetes that may be lipocalin-dependent in the liver but not in skeletal muscle. Pioglitazone potassium (oral gavage, 10 mg/kg, once daily, 4 weeks) can significantly reduce body weight (BW), cardiac hypertrophy, elevated blood glucose levels and improve the associated dyslipidemia.

Storage & Handling

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

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