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SRS11-92
Cat. No. IC23065
CAS. No. 1467047-25-1
Key Features and Details
Category
Inhibitor&Activator
Purity
98.09%
Formula
C22H28N2O2
Product Details
Product Name
SRS11-92
CAS No.
1467047-25-1
Molecular Weight
352.47
Formula
C22H28N2O2
Appearance
Powder
Purity
98.09%
SMILES
O=C(C1=CC=C(NC2CCCCC2)C(NCC3=CC=CC=C3)=C1)OCC
Product Overview
Description
SRS11-92, a Ferrostatin-1 (Fer-1) analogue, is a potent ferroptosis inhibitor. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells (EC50=6 nM).
In Vitro Activity
SRS11-92 fully protects oligodendrocytes (OLs) from cystine deprivation when tested at 100 nM. SRS11-92 rescues primary human fibroblasts from death induced by frataxin knock-down.
In Vivo Activity
SRS11-92, used at 500 nM, is efficacious in protecting human and mouse cellular models of Friedreich ataxia (FRDA) treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO), whereas caspase-3 inhibitors fail to show significant biological activity.
Storage & Handling
Storage
4 °C, protect from light
In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)
Shipping
Room temperature in continental US; may vary elsewhere.
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