Antitumor Agent-77

Cat. No. IC23213

CAS. No.

Key Features and Details

Category

Inhibitor&Activator

Formula

C7H11F3N2O5Pt

Product Size

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Product Details

Product Name

Antitumor Agent-77

Molecular Weight

455.25

Target

COX-2 Bax Bcl-2

Formula

C7H11F3N2O5Pt

SMILES

[NH3][Pt]1(OC(C2(C(O1)=O)CC(C(F)(F)F)(C2)O)=O)[NH3]

Product Overview

Description

Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells.

In Vitro Activity

Antitumor agent-77 (compound 2a) (30 μM; 4 h) exhibits better solubility and improved cellular uptake than Carboplatin in A549 cells. Antitumor agent-77 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells. Antitumor agent-77 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease. Antitumor agent-77 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase. Antitumor agent-77 (10 μM; 12 h) inhibits cells migration with inhibition rate of 52%.

In Vivo Activity

Antitumor agent-77 (compound 2a)exhibits similar potency compared with Oxaliplatin, without significant damage to kidney and liver as well as weight loss.

Storage & Handling

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere.

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