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YL-939
Cat. No. IC23025
CAS. No.
Product Details
Product Name
YL-939
Molecular Weight
426.51
Formula
C25H26N6O
Product Overview
Description
YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis.
In Vitro Activity
YL-939 (0.01-10 μM) efficiently protects cells from ferroptosis with IC50 values of 0.14 μM, 0.25 μM, 0.16 μM, 0.16 μM and 0.24 μM for HT-1080, Miapaca-2, Calu-1, HCT116 and SHSY5Y cells, respectively.
YL-939 (5 μM; 10 h; ES-2 cells) reduces the level of ROS in cytosolic, membrane lipids.
YL-939 (5 μM; 1-10 h; ES-2 cells) has a biological target of PHB2.
YL-939 (3 μM; 10 h; ES-2 cells) improves ferritin protein expression in a concentration-dependent manner and blocks autophagosomes/lysosomes, and hence inhibited ferritinophagy.
In Vivo Activity
YL-939 ameliorates liver damage in an Acetaminophen (APAP)-induced acute liver injury model.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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