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DL-Buthionine-(S,R)-sulfoximine hydrochloride
Cat. No. IC23164
CAS. No.
Key Features and Details
Category
Inhibitor&Activator
Purity
≥98.0%
Formula
C8H19ClN2O3S
Product Details
Product Name
DL-Buthionine-(S,R)-sulfoximine hydrochloride
Molecular Weight
258.77
Synonyms
Buthionine sulfoximine hydrochloride; BSO hydrochloride
Formula
C8H19ClN2O3S
Appearance
Solid
Purity
≥98.0%
SMILES
OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl
Product Overview
Description
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
In Vitro Activity
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine.
In Vivo Activity
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.
Storage & Handling
Storage
4 °C, sealed storage, away from moisture and light
*In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)
Shipping
Room temperature in continental US; may vary elsewhere.
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