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Sorafenib-13C,d3
Cat. No. IC23202
CAS. No. 1210608-86-8
Key Features and Details
Category
Inhibitor&Activator
Formula
C2013CH13D3ClF3N4O3
Product Details
Product Name
Sorafenib-13C,d3
CAS No.
1210608-86-8
Molecular Weight
468.84
Formula
C2013CH13D3ClF3N4O3
SMILES
O=C(NC(C=C1)=CC=C1OC2=CC(C(N[13C]([2H])([2H])[2H])=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Product Overview
Description
Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator.
In Vitro Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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