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Lapatinib-d5
Cat. No. IC23181
CAS. No. 2748212-14-6
Key Features and Details
Category
Inhibitor&Activator
Formula
C29H21D5ClFN4O4S
Product Details
Product Name
Lapatinib-d5
CAS No.
2748212-14-6
Molecular Weight
586.09
Synonyms
GW572016-d5; GW2016-d5
Formula
C29H21D5ClFN4O4S
SMILES
O=S(CC([2H])([2H])NCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C([2H])([2H])[2H])=O
Product Overview
Description
Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
In Vitro Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Storage & Handling
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping
Room temperature in continental US; may vary elsewhere.
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