Withaferin A

Cat. No. IC23145

CAS. No. 5119-48-2

Key Features and Details

Category

Inhibitor&Activator

Purity

99.61%

Formula

C28H38O6

Product Size

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Product Details

Product Name

Withaferin A

CAS No.

5119-48-2

Molecular Weight

470.60

Formula

C28H38O6

Appearance

Solid

Purity

99.61%

SMILES

C[C@]([C@](CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@@H]([C@@](O3)([H])CC(C)=C(CO)C3=O)C)([H])[C@@]2([H])C4)(C(C=C5)=O)[C@@]6([C@H]5O)[C@@H]4O6

Product Overview

Description

Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

In Vitro Activity

Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).

In Vivo Activity

Withaferin A shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.

Storage & Handling

Storage

4 °C, protect from light In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Shipping

Room temperature in continental US; may vary elsewhere.

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