Online Inquiry
ML162
Cat. No. IC23147
CAS. No. 1035072-16-2
Key Features and Details
Category
Inhibitor&Activator
Purity
99.52%
Formula
C23H22Cl2N2O3S
Product Details
Product Name
ML162
CAS No.
1035072-16-2
Molecular Weight
477.40
Formula
C23H22Cl2N2O3S
Appearance
Solid
Purity
99.52%
SMILES
O=C(CCl)N(C(C1=CC=CS1)C(NCCC2=CC=CC=C2)=O)C3=CC=C(OC)C(Cl)=C3
Product Overview
Description
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines
In Vitro Activity
ML162 (compound 1a) shows nanomolar potencies against two HRASG12V expressing cell lines, with IC50 values of 25 nM and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively.
ML162 (8 μM; 24 hours) treatment increases the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells, inactivates Keap1, and increases expression of the phospho-PERK-ATF4-SESN2 pathway.
ML162 induces the head and neck cancer (HNC) cell death to varying degrees, with parental HN3 cells more sensitive and cisplatin-resistant (HN3R) and acquired RSL3-resistant (HN3-rslR) cells less sensitive.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Related Products