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Roxadustat
Cat. No. IC23123
CAS. No. 808118-40-3
Key Features and Details
Category
Inhibitor&Activator
Purity
99.68%
Formula
C19H16N2O5
Product Details
Product Name
Roxadustat
CAS No.
808118-40-3
Molecular Weight
352.34
Synonyms
FG-4592
Formula
C19H16N2O5
Appearance
Solid
Purity
99.68%
SMILES
O=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=CC=CC=C3)C=C2)=O
Product Overview
Description
Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.
In Vitro Activity
Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.
Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells.
In Vivo Activity
Roxadustat protects the survival of motor neurons and improves recovery from spinal cord injury.
Storage & Handling
Storage
Powder, -20 °C, 3 years; 4 °C, 2 years
In solvent: -80 °C, 6 months, -20 °C, 1 month.
Shipping
Room temperature in continental US; may vary elsewhere.
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