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- Dacryocystitis
Dacryocystitis refers to inflammation of the lacrimal sac, which is the part of the eye's drainage system. At Protheragen, we specialize in providing comprehensive and customized solutions for dacryocystitis, including advanced diagnostic development and innovative therapeutic development services.
Dacryocystitis is an inflammatory condition of the lacrimal sac which is most often caused by an obstruction of the nasolacrimal duct. This obstruction causes a tear and debris buildup which has the potential to foster bacterial infection. It may present as either acute or chronic conditions, with acute cases having severe signs such as redness, increased heat, and severe discomfort; chronic cases tend to have tearing and some discharge. Dacryocystitis is more common among the adult female population and young infants, and has the potential to cause eye infectious complications if left untreated.
Fig. 1 Axial post-contrast CT scan image. (Aleid S., et al., 2021)Culture and Sensitivity Testing
Culture and sensitivity testing is critical for the diagnosis of dacryocystitis. In order to identify the infecting bacterium, samples are generally obtained from the lacrimal sac via puncture and aspiration. In more severe forms of the disease, or in younger patients, blood cultures may be performed to eliminate the possibility of a systemic infection. This approach enables precise detection of the infectious organisms and ensures targeted therapeutics with antibiotics.
Microbiological Analysis
Identification of pathogens is becoming more accurate and rapid with the application of advanced microbiological technologies, including PCR (Polymerase Chain Reaction) and MALDI-TOF MS (Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry) . These techniques enhance precision in diagnostics by providing a comprehensive insight into the microbial profile and determining minimal infection levels.
The therapeutic regimen for dacryocystitis focuses primarily on drug therapeutics with the use of antibiotics aimed at controlling the infection. Broad-spectrum antibiotics are usually given, which include amoxicillin-clavulanic acid, gentamicin, and ciprofloxacin. In young children, more potent intravenous antibiotics like amoxicillin-clavulanic acid are commonly used because of the greater risk of intravascular dissemination. Local antibiotics and anti-inflammatory agents may also be employed for the mitigation of local symptoms and to provide prophylaxis against future infections. Efforts to assist maintenance, such as warm fomentations and massage over the lacrimal sac to aid in the fixation of cyst and sac drainage, can reduce cyst and sac inflammation.
Protheragen devotes itself to identifying complex problems such as dacryocystitis, both therapeutically as well as diagnostically, with efficient solutions. Our diagnostic services incorporate the latest microbiological analysis techniques, which include rapid and accurate pathogen identification using PCR and MALDI-TOF MS. Moreover, we focus on developing new antibiotics and targeted therapies to combat the evolving microorganisms associated with dacryocystitis.
By leveraging cutting-edge science and translational expertise, Protheragen accelerates the development of next-generation diagnostics and therapeutics for dacryocystitis. If you are interested in our services, please feel free to contact us.
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