Evaluation of Anti-Stroke Drugs
Stroke is a disease that affects the brain and the internal arteries of the brain and is the leading cause of death. Screening and evaluation of safe and effective anti-stroke drugs can help in the treatment and prevention of the disease.
Our company is focused on providing effective, complete solutions for our clients' anti-stroke drug screening, based on our extensive testing experience and best-in-class testing platform.
What Is A Stroke
Stroke, also known as transient ischemic attack or cerebrovascular accident, is an acute brain disease. Usually, a sudden rupture of a blood vessel in the brain or a blockage of a blood vessel that prevents blood from flowing to the brain can cause damage to brain tissue, resulting in a stroke. Long-term strokes can lead to brain damage, disability and even death. The brain serves as a high-level nerve center that controls many aspects of the body, including sensation, cognition, and movement and the normal function of the brain requires oxygen. The blood vessels carry oxygen-rich blood to all parts of the brain. If a stroke occurs, brain cells will be damaged or even die within a short period of time, resulting in damage to the brain and the body will not be able to work properly.
Fig. 1 Schematic representation of the detrimental events following ischemic stroke. (Jayaraj, 2019)
Approaches to The Evaluation of Anti-stroke Drugs
Anti-stroke drugs are usually evaluated in animal models of stroke for post-stroke motor and coordination abilities to determine whether the drug is effective in recovering from neurological damage after stroke. In addition, studies have shown that cognitive deficits after stroke can sustain beyond general sensorimotor function. Therefore, neurobehavioral evaluation of animal models of stroke also involves the evaluation of cognitive behavior.
Our company provides behavioral assessments for anti-stroke drug screening including, but not limited to the following.
| Motor and Coordination Ability | ||
|---|---|---|
| Beam balance test | Rotarod test | Muscle strength test |
| Inverted screen test | Limb symmetry test | Forelimb placement test |
| Pole test | Ladder rung walking test | Rope climbing test |
| Forepaw extension and flexion test | Gait analysis test | |
| Cognitive Ability | ||
| Morris water maze test | Eight-arm maze test | T maze test |
Drug Screening and Evaluation Process of Our company
Our company offers a customized testing process based on your specific research needs, including the selection of test subjects, the selection of test methods, the execution of experimental protocols, and data analysis.
Our company applies our specialized behavioral tests to the screening and safety assessment of anti-stroke drugs. We are committed to providing valuable reference results for our clients' drug development projects. If you are interested, please contact us and describe your specific research, and we will be happy to assist you.
Reference
- Jayaraj, R. L.; et al. Neuroinflammation: friend and foe for ischemic stroke. Journal of neuroinflammation. 2019, 16(1): 1-24.