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Digestive System Diseases

Digestive system diseases include organic and functional diseases of the esophagus, stomach, intestines, liver, gallbladder, pancreas, and other organs. As a company focused on rare diseases, we pride ourselves on our ability to tailor innovative drugs and therapies to address the unique challenges posed by rare digestive system diseases.

Introduction to Digestive System Diseases

Digestive system diseases refer to a group of disorders that affect the structure or function of the digestive system. These diseases can arise from a variety of causes, including genetic factors, infections, autoimmune responses, lifestyle choices, and environmental factors. Rare digestive system diseases include familial adenomatous polyposis (FAP), non-alcoholic steatohepatitis (NASH), gastrointestinal stromal tumor (GST), hepatic fibrosis, and polycystic liver disease (PCLD).

Pathogenesis of Digestive System Diseases

In the etiology of certain digestive disorders, genetic predisposition plays a substantial role. For instance, conditions like Crohn's disease and celiac disease have been identified to have a strong genetic component. Additionally, infections caused by pathogens like Helicobacter pylori can lead to the formation of peptic ulcers, primarily affecting the stomach. Autoimmune responses are also implicated in the pathogenesis of digestive disorders, such as ulcerative colitis, where the immune system mistakenly attacks and damages the intestinal lining.

Expression and distribution of P2X receptor in the digestive system.Fig.1 Expression and distribution of P2X receptor in the digestive system. (An, Qimin, et al., 2021)

Targets for Digestive System Disease Therapy Development

Inflammatory Pathways

Inflammatory processes are central to many digestive system diseases, such as IBD. Targeting specific inflammatory molecules and pathways, such as tumor necrosis factor-alpha (TNF-α) or interleukin-23 (IL-23), can help alleviate inflammation and restore normal gut function.

Acid Secretion Regulation

Disorders like GERD and peptic ulcers are often associated with abnormal acid secretion. Targeting proton pump enzymes, which are responsible for acid production, can effectively reduce acid reflux and promote healing of ulcers.

Gut Microbiota Modulation

Emerging evidence suggests that an imbalance in gut microbiota composition can contribute to digestive system diseases. By targeting specific bacteria or introducing beneficial microorganisms, therapies can help restore a healthy gut microbiome and improve digestive health.

Metabolic Pathways

Liver diseases and pancreatic disorders often involve disruptions in metabolic processes. Targeting enzymes, receptors, or transporters involved in metabolism can help restore normal function and alleviate symptoms.

Our Services

To develop effective therapies, it is crucial to understand the underlying causes of digestive system diseases. Our extensive research and analysis have identified multiple factors contributing to these diseases. We provide a wide range of consumer system diagnostics and therapeutics development services, providing pharmaceutical companies with one-stop solutions.

Rare Types of Digestive System Diseases

Therapy Development Platforms

Our preclinical studies involve the evaluation of therapeutic candidates in relevant animal models of digestive system diseases. In addition, we provide different types of experimental animals including mice, rats, pigs, and monkeys to support drug safety evaluation and pharmacokinetic analysis. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

References

  • An, Qimin, et al. "Pathophysiological role of purinergic P2X receptors in digestive system diseases." Frontiers in Physiology 12 (2021): 781069. 
  • Bates, Michael D., and Gail H. Deutsch. "Molecular insights into congenital disorders of the digestive system." Pediatric and Developmental Pathology 6 (2003): 284-298.
  • Wu, Xianli, et al. "Exosome-mediated effects and applications in inflammatory diseases of the digestive system." European Journal of Medical Research 27.1 (2022): 163.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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