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Antibody Production Service

With the development of biotechnology, antibody therapy has been widely used in the treatment of rare diseases due to its good efficacy and high safety. Our company provides high-quality antibody production services and has a variety of antibody production platforms to help you make progress in the development of antibody therapy for rare diseases.

Types of Antibody Therapies

Antibody therapy is mainly divided into monoclonal antibody and polyclonal antibody. The monoclonal antibody is secreted by a single B lymphocyte, which is highly specific and can identify pathogens more accurately. The polyclonal antibody is composed of a variety of antibodies, which can recognize multiple antigen epitopes and improve the sensitivity of immune determination. It is widely used in the diagnosis and research of disease.

2-2-4-5 Antibody Production Service-1Fig.1 Workflow for scFvs conversion into full mAbs (Zambrano, Nicola, et al. 2022)

When selecting the appropriate antibody clone for rare disease antibody therapy, several key parameters must be considered. The following table compares the advantages and drawbacks of producing monoclonal antibodies and producing polyclonal antibodies.

Types Advantages Drawbacks
Monoclonal antibodies
  • Better specificity with minimal and less background reactivity.
  • Unlimited antibody quantity of antibody.
  • Potential for DNA sequencing and modifications.
  • Possibility to sequence and engineer.
  • Potential for decreased immunogenicity and antibody sensitivity.
  • Time-consuming and expensive to make.
Polyclonal antibodies
  • Potentially for enhanced immunogenicity and antibody sensitivity.
  • Reduced sensitivity to antigen conformational variations.
  • Quick and inexpensive to produce.
  • Background risk due to cross-reactions.
  • Limited quantity of antibody.
  • Batch Variability between batches.

Our Services

Our company provides comprehensive customized antibody production services, including a variety of monoclonal antibodies and polyclonal antibody-related production services, to meet your research needs in antibody therapy.

  • Monoclonal Antibodies Production Service

We have a proven track record in developing rare disease monoclonal antibodies, utilizing a range of proprietary technologies to maximize your chances of generating highly specific and high-affinity antibodies. Our custom antibody service is tailored to accommodate projects of varying complexity. Our services include but are not limited to:

Service Content
  • Recombinant antibody production
Antibody formats: Fab, scFv, sdAb/VHH, Fc fusion proteins, chimeric antibodies, and bispecific antibodies.
  • Stable cell lines for monoclonal antibody production
Stable cell lines and selection systems: CHO, HEK, BHK, NS0, among others.
  • Hybridoma cell culture for monoclonal antibody production
Production Method: Medium With serum, Serum-free Medium, Animal-free Medium
  • High throughput antibody production
The use of mammalian expression systems offers a rapid and reliable solution for producing dozens or even hundreds of antibodies.
  • Polyclonal Antibody Production Service

Our comprehensive polyclonal antibody services include the production of custom polyclonal antibodies in SPF animals. Our company provides one-stop solutions for your custom polyclonal antibody production, taking your project all the way from animal immunization to antibody purification and QC analysis.

Service Content
Host for polyclonal antibody production
  • Rabbits
  • Sheep and Goats
  • Chicken
  • Llama and Alpaca
Polyclonal antibody purification
  • Protein A or G purification
  • Antigen-specific purification

Antibody Production Workflow

2-2-4-5 Antibody Production Service-2Expression vector construction
2-2-4-5 Antibody Production Service-3
2-2-4-5 Antibody Production Service-4Gene expression
2-2-4-5 Antibody Production Service-3
2-2-4-5 Antibody Production Service-5Antibody purification
2-2-4-5 Antibody Production Service-3
2-2-4-5 Antibody Production Service-6Quality control

Our company has the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease therapy research projects. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

Reference

  • Zambrano, Nicola, et al. "High-throughput monoclonal antibody discovery from phage libraries: challenging the current preclinical pipeline to keep the pace with the increasing mAb demand." Cancers 14.5 (2022): 1325.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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