Phototoxicity evaluation is used to study the toxic response of a substance to the human body. Our company has long-term devoted to developing and applying rare disease drug safety evaluation. With years of experience, our scientists have the capabilities and resources to provide one-stop phototoxicity evaluation services to advance the rare disease therapy research and project goals of our global clients.
Introduction to Phototoxicity Evaluation
Phototoxicity refers to a toxic response caused by a substance applied to the body that is excited or increased after subsequent exposure to the light, or by skin irradiation after systemic administration of a substance. Preclinical phototoxicity evaluation is generally divided into in vivo evaluation and in vitro evaluation. Phototoxicity is a common phenomenon in humans and may cause damage to skin cells and tissues, such as edema, itching, stinging, skin cancer, cataracts, etc. Types of drugs that may have phototoxicity include:
- Thiazide diuretics
Occurrence of Phototoxicity
Sunlight is composed of visible, infrared, and ultraviolet, each of which has a different wavelength range. Since some drugs convert to an excited state after absorbing energy at the corresponding wavelength, the excited state is converted to the ground state to absorb the transferred energy and generate reactive oxygen species (ROS), the increased ROS leads to the production and release of inflammatory mediators and cytokines by damaging DNA and cell membrane, and eventually leads to the occurrence of phototoxicity.
With the continuous expansion and improvement of the company over the years, our company has a complete light source configuration and detection system. We can use a variety of light sources, including visible light, xenon arc solar simulator, and fluorescent UV radiation source, to provide customers with professional phototoxicity evaluation services, such as cutaneous phototoxicology, ocular toxicology, visceral phototoxicology, and other services.
|In Vivo Phototoxicity Evaluation||In Vitro Phototoxicity Evaluation|
Why Choose Us?
- Competitive pricing and fast turnaround time
- Careful design and transparent operation process
- Exceptional post-sales support
- One-stop platform with experienced technical team.
- Automation-friendly phototoxicity evaluation workflow
- High data quality and reliable analysis
With extensive experience in rare disease therapy research and development, our company provides customers with a cost-effective and convenient solution. Our phototoxicity evaluation service is a simplified workflow by a group of specially trained and professional scientists. We are pleased to use our advanced platform to offer the best service and the most qualified products to satisfy each demand from our customers. If you are interested in our services, please feel free to contact us for more information.
- Bauer, D., et al. "A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10." Regulatory Toxicology and Pharmacology 125 (2021): 105017.
For Research Use Only.