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Please note that we are not a pharmacy or clinic, so we are unable to see patients and do not offer diagnostic and treatment services for individuals.


Local Toxicity Evaluation

Local toxicity evaluation is used to study the toxic reactions caused by topical administration and is an important part of toxicology studies. Our company offers comprehensive services and technical support covering every stage of preclinical rare disease therapy research and development, designed to help our clients address possible barriers and challenges in local toxicity evaluation for rare diseases.

What Is Local Toxicity Evaluation?

Local toxicity refers to the direct damage caused by certain drugs at the contact site of the body, which initially manifests as cell death at the direct contact site. Dosage forms such as ointments, drops, lotions, scalp patches, sprays, and topical powders generally require local toxicity testing of the drug. Factors causing local toxicity include:

  • Pharmaceutical active ingredients or components
  • New ingredients produced after compatibility
  • Metabolites in the body
  • Impurities during preparation
  • Physical and chemical properties of preparations

How Is Local Toxicity Evaluation Performed?

Animal Species Drug Types Administration Routes Study Content
  • Mice
  • Rats
  • Guinea
  • Pigs
  • Rabbits
  • Beagles
  • Others
  • Small molecules
  • Biomolecules
  • Natural products
  • Vaccines
  • Others
  • Gavage
  • Intraperitoneal injection
  • Intravenous injection
  • Intramuscular injection
  • Intradermal injection
  • Subcutaneous injection
  • Nasal cavity
  • Rectum
  • Vagina
  • Others
  • Hemolysis: refers to reactions such as hemolysis and red blood cell aggregation caused by drug preparations.
  • Allergy: refers to a specific immune response that manifests as tissue damage or physiological dysfunction after the body is re-stimulated by the same antigen. It is an abnormal or pathological immune response.
  • Irritation: refers to the reversible inflammatory response to the administration site after administration of parenteral preparations.

Our Services

With many years of experience in safety evaluation services and a proven track record of quality, innovation, and customer support, our company provides comprehensive local toxicity evaluation services to leading and emerging biopharmaceutical companies and scientific research institutions.

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Hemolysis Evaluation

  • In vivo hemolysis evaluation
    Our company provides animal model platform for in vivo hemolysis evaluation.
  • In vitro hemolysis evaluation
    Provides services such as direct red blood cell count, ultraviolet spectrophotometric.
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Allergy Evaluation

  • Active systemic anaphylaxis
  • Passive cutaneous anaphylaxis
  • Active cutaneous anaphylaxis
  • Skin photoallergy test
  • Guinea-pig maximization test
  • Buehler test
  • Murine local lymph node assay
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Irritation Evaluation

  • Blood vessel stimulation
  • Eye irritation/corrosion
  • Vaginal mucosal irritation
  • Skin irritation
  • Ear irritation
  • Mucosa irritation
  • Rectal irritation
  • Nasal drops and inhalant irritation

Why Choose Us?

  • Cost-effective compared to other companies
  • Careful design and transparent operation process
  • Providing standardized upstream platform solutions
  • One-stop platform with experienced technical team.
  • Exceptional post-sales support
  • High data quality and reliable analysis

Project Workflow

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As an integrated CRO, our company has the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease research projects. We provide comprehensive immunogenicity and immunotoxicity evaluation services to leading and emerging biopharmaceutical companies and scientific research institutions. If you are interested in our services, please feel free to contact us for more information.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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