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Embryo-fetal Development Toxicity Evaluation

Embryo-fetal development (EFD) toxicity evaluation is the second segment of developmental and reproductive toxicology evaluation. With many years of experience in rare disease therapy research and a proven track record of quality, innovation, and customer support, our company provides comprehensive services for embryo-fetal development toxicity evaluation to leading and emerging biopharmaceutical companies and scientific research institutions.

Overview of Embryo-fetal Development Toxicity Evaluation

Embryo-fetal development toxicity evaluation is also known as embryotoxicity, teratology, developmental toxicity with prenatal evaluation, or segment II study. The study aimed to detect the adverse effects of drug toxicity on pregnant females and on embryonic and fetal development.

Methods of Embryo-fetal Development Toxicity Evaluation

Embryonic-fetal development evaluation is generally performed in rats and rabbits, and experiments are performed by various routes of administration, such as dietary, dermal, oral gavage, intravenous injection, subcutaneous, etc. Usually, the rat is administered between gestational days 6 and 15, and the rabbit is administered between gestational days 6 and 18. Female experimental animals were euthanized approximately before parturition; normally, rats were euthanized approximately 20/21 days of gestation, and rabbits were euthanized approximately 28/29 days of gestation.

1-3-2-3-2 Embryo-fetal Development Toxicity Evaluation-1 Fig.1 Study design for embryo-fetal developmental toxicity in rats and rabbits. (Li, Ronghua, et al., 2018)

Our Services

As an integrated CRO, our company has extensive experience and the ability to provide experimental animals as well as microdissection techniques, Wilson technique, and single & double staining techniques to support embryo-fetal developmental toxicity evaluation services. The embryo-fetal developmental toxicity evaluation services we can provide include but are not limited to the following:

  • Dose-range Finding
    Experienced toxicologists from our company study and design reasonable dose ranges for determining maternal toxicity and maximum tolerated dose levels, and ensure that there are ultimately enough experimental animals for embryo-fetal developmental toxicity analysis.
  • Embryo-fetal Evaluation
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Experimental Animals

With advanced platforms and technologies, rodents and non-rodent animals are provided for studies, with rats and rabbits generally recommended.

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Dosing Methods

The drug dosing method is designed according to the corresponding project requirements, generally from embryo implantation to hard palate closure.

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Observation Indicators

During the experiment, the animals' physical signs, death, body weight, food intake and other indicators are observed. and the progress of the experiment is reported to the client at any time.

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Animal Euthanasia

Providing you with visceral examination, craniofacial examination, and bone and cartilage examination, and providing a complete fetal pathology report according to client’s needs.

Capabilities of our company

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  • Providing standardized upstream platform solutions
  • Superior data quality and fast turnaround
  • One-stop platform with an experienced technical team
  • Reducing costs and time by enabling more efficient processes through service expertise
  • Careful design and transparent operation process

Project Workflow

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Our company has extensive expertise in drug safety evaluation, particularly in embryo-fetal development toxicity evaluation. We have the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease therapy research projects. If you are interested in our services, please feel free to contact us for more information.

Reference

  • Li, Ronghua, et al. "An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits." Toxicology Research 7.6 (2018): 1225-1235.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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