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Peptide Characterization Service

In the field of peptide drug development for rare diseases, understanding the structure and properties of peptides is crucial. Our company offers a full range of peptide characterization services, which can help you make progress in the development of rare disease peptide therapies.

Introduction to Peptide Characterization

Peptide characterization plays a crucial role in researching and developing treatments for rare diseases. It helps understand peptide structure and function, enabling the discovery and optimization of potential therapies. It provides insights into how peptides interact with disease pathways and targets, improving peptide stability and activity. Overall, peptide characterization advances the understanding and treatment of rare diseases.

2-2-5-4 Peptide Characterization Service -1Fig.1 Characterization of synthetic peptide therapeutics using liquid chromatography-mass spectrometry (Lian, Zhirui, et al. 2021)

In the field of rare diseases, peptide characterization plays a critical role in research and drug development. By studying the composition, structure, and modifications of peptides, scientists can gain a better understanding of their biological functions and potential therapeutic uses. This knowledge allows for the discovery and optimization of lead peptides, improving their stability and physiological activity through targeted modifications. Comprehensive peptide analysis services offer the necessary tools to identify and analyze peptides, facilitating advancements in rare disease peptide drug development.

Our Services

Our company offers a range of services designed to meet the specific needs of researchers and developers in the field of peptide analysis and characterization. These services leverage advanced technologies and methodologies, delivering accurate and reliable results.

Sequence Determination Amino Acid Analysis
  • The gold standard method to quantify a peptide
  • Reversed-phase liquid chromatography
Peptide Mapping Peptide mapping can be used to characterize
  • N-glycosylation sites
  • Disulfide linkages
  • N-terminal pyroglutamic acid
  • C-terminal lysine clipping
Peptide Sequencing
  • Edman degradation method
  • Separated and identified by HPLC
Properties Analysis Peptide Purity Analysis
  • Reversed Phase HPLC: Monitored at 214 nm
  • Mass Spectrometry: It can show impurities in the peptide products.
Water Content Analysis Two types of Karl Fischer titration exist
  • Coulometric titration
  • Volumetric titration
NMR Analysis Determine the primary structure and the components of impurities in peptides
Solubility Test
  • Qualitative solubility test: Ultrapure water, 1 x DPBS, DMSO
  • Quantitative solubility test: Quantitative test report for specified solvents
Optional Services TFA Removal
  • HPLC
  • Inion exchange chromatography
  • Lyophilization protocol
Endotoxin Control Delivering custom peptides with desired purity and quantity at a guaranteed endotoxin level of <0.01 EU/μg

Project Workflow

2-2-5-4 Peptide Characterization Service -2

Through the application of advanced characterization techniques, researchers can gain a deep understanding of peptide properties, stability, and interactions, contributing to the design and optimization of peptide-based therapies for rare diseases. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

Reference

  • Lian, Zhirui, et al. "Characterization of synthetic peptide therapeutics using liquid chromatography–mass spectrometry: Challenges, solutions, pitfalls, and future perspectives." Journal of the American Society for Mass Spectrometry 32.8 (2021): 1852-1860.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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