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Repeated-dose Toxicity Evaluation

Repeated-dose toxicity evaluation is of great significance in estimating the starting dose and safe dose range for clinical trials. Our company employs talented and highly trained scientists who focus on every aspect of rare disease drug safety evaluation and can customize experimental designs for your project and carry out entire repeated dose toxicity evaluations to accelerate your research on the treatment of rare diseases.

Introduction to Repeated-dose Toxicity Evaluation

Repeated-dose toxicity evaluation can determine the adverse toxicological effects of repeated daily dosing of a substance within a specific period. The study duration can be 14 days, sub-chronic studies up to 3 months, and chronic studies beyond 3 months up to 2 years.

1-3-2-1-2 Repeated-dose Toxicity Evaluation-1 Fig.1 Typical process for subacute repeat-dose toxicity evaluation. (Saleem, U., et al., 2017)

In principle, repeated dose toxicity evaluation should have at least three dose groups: low, medium, and high, and a control group. The low dose is equivalent to or higher than the effective dose for animals or the equivalent dose for clinical use. The medium dose should be set between the high dose and the low dose based on the mechanism and characteristics of toxic effects. A successful repeated-dose toxicity study can determine a safe dose level and provide a general characterization of toxicity.

Our Services

The evaluation of repeated-dose toxicity is inseparable from our company's comprehensive animal species platform support, our toxicology team can also provide dose-ranging study services, typically we set up three dose levels. Our experienced DMPK and bioanalytical teams provide maximum support for toxicology evaluation.

Sub-acute repeat-dose toxicity evaluation

Top experts perform sub-acute toxicity experiments based on acute toxicity experiments. The test period is generally 2 weeks or 4 weeks to further verify the impact of toxicity and prepare for chronic toxicity tests.

Sub-chronic repeat-dose toxicity evaluation

Providing sub-chronic toxicology studies with a 90-day experimental cycle, and rodent and non-rodent animals are usually selected for experiments. We can also provide customized services according to client's needs.

Chronic repeat-dose toxicity evaluation

Experienced scientists use advanced technology to provide rodent chronic toxicity studies and combined chronic toxicity/carcinogenicity studies to fully meet the different needs of clients.

Service Highlights

1-3-2-1-2 Repeated-dose Toxicity Evaluation-2
  • Automation-friendly workflow
  • Superior data quality and fast turnaround
  • Cost-effective compared to other companies
  • Careful design and transparent operation process
  • Exceptional post-sales support
  • One-stop platform with an experienced technical team

Project Workflow

1-3-2-1-2 Repeated-dose Toxicity Evaluation-3

As an integrated CRO, our company provides clients with a cost-effective and convenient solution. Our repeated-dose toxicity evaluation service is a simplified workflow by a group of specially trained and experienced scientists. We have the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of rare disease therapy research. If you are interested in our services, please feel free to contact us for more information.

Reference

  • Yang, M., et al. "Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice." Food and Chemical Toxicology 131 (2019): 110534.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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