Allergy Evaluation
Drug allergy is a reaction caused by drugs and is a special type of adverse drug reaction. Our company's allergy evaluation service is a simplified workflow by a group of specially trained and experienced scientists. We offer comprehensive services and technical support, designed to help our clients address possible barriers and challenges in rare disease therapy research and development.
Introduction to Allergy
Allergy refers to a specific immune response that manifests as tissue damage or physiological dysfunction after the body is re-stimulated by the same antigen. It is an abnormal or pathological immune response. Drug allergies generally occur after multiple exposures to the same drug. There is an incubation period for the first onset, but the recurrence can occur immediately. It occurs due to an abnormal immune response, which is generally harmful to the human body. Allergies are generally divided into four types.
Allergy
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Type I
Common symptoms:
rash, itching, sneezing, runny nose, asthma attack, etc.
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Type II
Common symptoms:
anemia, bleeding purpura, etc.
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Type III
Common symptoms:
fever swollen lymph nodes, joint swelling and pain, kidney damage, etc.
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Type IV
Common symptoms:
eczema, herpes, skin pigmentation, etc.
Animal Models for Allergy
Animal models are very important for allergy evaluation. They are the premise of screening allergens in drugs and the basis of preventing the occurrence of allergic reactions to drugs. Mice and rats are widely used in allergy evaluation. Among them, mice are commonly used as experimental animals for drug sensitization models due to their diverse immunological and molecular reactions. SD rats have the advantages of high sensitivity and good reproducibility. In addition, beagles, miniature pigs, and guinea pigs are also additional choices for allergic reaction research models.
Our Services
- Design of Allergy Evaluation
Dose design
Multiple doses are generally selected, including the highest dose.
Statistical methods
Choose appropriate statistical methods based on the experimental model and test methods.
Control group
Establish a positive control group and a negative control group, or select a marketed preparation as a control.
- Content of Allergy Evaluation
Our company provides appropriate allergy evaluation services based on drug characteristics, indications, administration methods, occurrence mechanisms, influencing factors, etc.
Services we can provide include but are not limited to:
- Active systemic anaphylaxis
- Passive cutaneous anaphylaxis
- Active cutaneous anaphylaxis
- Skin photoallergy test
- Guinea-pig maximization test
- Buehler test
- Murine local lymph node assay
Why Choose Us?
- Customized services and products tailored to your research
- Ph.D.-level scientists and skilled technicians
- The rich experience accumulated in successful cases of new drug development
- High data quality and reliable analysis
- Fast and cost-efficient workflow
- Expertise and experience in the industry
Project Workflow
As an integrated CRO, our company provides clients with a cost-effective and convenient solution. Our allergy evaluation service is a simplified workflow by a group of specially trained and experienced scientists. We have the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease therapy research projects. If you are interested in our services, please feel free to contact us for more information.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
