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Cardiovascular System Evaluation

Cardiovascular system evaluation helps determine the potential adverse effects of drugs on the cardiovascular system. Our company has extensive expertise and resources in drug safety evaluation, particularly in cardiovascular system evaluation. We employ scientists with broad expertise to direct and conduct one-stop cardiovascular evaluation services for rare disease therapy research and development and provide timely project reports and excellent after-sales service, you can fully trust us.

Introduction to Cardiovascular System Evaluation

The S7A guidance requires that all drug candidates be evaluated for their effects on blood pressure, heart rate, and electrocardiogram, so cardiovascular system evaluation is an essential step in preclinical studies, which are performed in rodents and large animals. It is important to note that rats have different mechanisms of ventricular repolarization than humans, large mammals, and guinea pigs and therefore should not be used to evaluate the effects of drugs on ventricular repolarization.

Cardiovascular system evaluation in safety pharmacology studies.Fig.1 Cardiovascular system evaluation in safety pharmacology studies. (Kim, Tae Rim, et al., 2021)

The purpose of cardiovascular safety pharmacology evaluation is to detect arrhythmogenic risks and potential effects on peripheral vessels, the heart, or any other effects that may secondarily lead to activation or suppression of cardiovascular function. These studies help to understand the safety of new drugs, provide pharmacological data, and can be used to optimize compounds and provide data support for clinical trials.

Telemetry for Cardiovascular System Evaluation

Telemetry is a technology for long-distance measurement of parameters of the object. Telemetry is used to conduct cardiovascular safety pharmacology research on awake animals, and the animals' ECG, blood pressure, and other indicators are observed, making the experimental results more objective, accurate, and close to clinical practice. The main advantage of telemetry studies is that they are performed under stress-free and physiological conditions. By applying telemetry to cardiovascular safety pharmacology evaluations, the measured physiological signals can better reflect the physiological conditions of animals in a normal and natural state.

Our Services

With the continuous construction of the platform and rich cooperation experience with global partners, our company provides you with fast and high-quality cardiovascular system evaluation services from a unique perspective.

  • Animal Models
    With extensive animal platform capabilities, our company provides rodents and large animals to support cardiovascular and cerebrovascular evaluation, including conscious and anesthetized animal models.
  • Parameter Detection
    The parameters our company can provide include but are not limited to:
  • Aortic blood pressure
  • Cardiac output
  • Stroke volume
  • Heart rate
  • ECG
  • Renal blood flow
  • Peripheral vascular resistance
  • Pulmonary artery blood pressure
  • Implantable Telemetry
    Telemetry recordings using smaller numbers of animals allow measurements to be made without the presence of laboratory personnel, providing you with physiological data on animals in their normal and natural state.

Why Choose Us?

Hemolysis Evaluation
  • Fast and cost-efficient workflow
  • Exceptional post-sales support
  • Superior data quality and fast turnaround
  • Cutting-edge technology and equipment
  • Innovative and flexible solutions
  • Reliable and trusted partner

Project Workflow

Project Workflow

As an integrated CRO, our company has the capabilities and resources to provide professional communication and problem-solving support to ensure that we can quickly respond to the changing needs of your rare disease research projects. We provide comprehensive cardiovascular system evaluation services to leading and emerging biopharmaceutical companies and scientific research institutions. If you are interested in our services, please feel free to contact us for more information.


  • Kim, Tae Rim, et al. "Safety pharmacology of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle platform." Toxicology Reports 8 (2021): 839-845.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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