Magnetic Nanoparticle Development Service
Gene delivery based on biocompatible magnetic nanoparticles has shown significant promise both in vitro and in vivo. Our company is dedicated to the design and synthesis of magnetic nanoparticles to develop non-viral gene delivery vectors with excellent levels of transfection. With our expertise in the development of gene delivery vectors, you can create effective therapeutic tools for a wide range of rare diseases.
Background
Magnetic-targeted delivery techniques are similar to drug delivery and have great potential for the delivery of therapeutic genes. Magnetic delivery offers great possibilities for solving current problems of effective delivery in gene therapy. In these systems, magnetic nanoparticles carry therapeutic or reporter genes, which are then focused onto the target site/cells by means of high field/high gradient magnets. This technique increases the concentration of the therapeutic gene while reducing the retention of the therapeutic gene elsewhere in the body.
In contrast to virus-based systems, these nanomaterial vectors have highly tunable surface properties, size, and composition. Recently, advances in nanomaterial technology have enabled researchers to prepare novel magnetic nanomaterial vectors as outstanding gene delivery vehicles that can be more effectively trapped and targeted. New strategies are being developed for applying magnetic fields, which could potentially be used in diseases such as cystic fibrosis, Huntington's disease, and localized cancerous tumors.
Fig.1 In vivo gene delivery using magnectofection. (Uthaman S, et al., 2016)
Our Services
Nanoscale dimensions, magnetic properties, and their ability to carry active biomolecules for specific tasks are essential characteristics of nanoparticles. We tailor solutions to the needs of our customers to enable easy localization/targeting within the human body. We offer a wide selection of magnetic materials including magnetite Fe3O4, maghemite γ-Fe2O3, iron-based metal oxides, iron alloys, and other materials. Furthermore, we offer a wide selection of coating materials including natural polymers, synthetic organic polymers, silica, gold, and organic linkers to suit different gene therapy applications. Our services include, but are not limited to:
- Synthesis of magnetic nanoparticles
We offer a wide range of methods for the synthesis of magnetic nanoparticles, mostly using basic chemistry, especially iron chemistry. Our methods include wet precipitation and co-precipitation, reverse micelle mechanism, chemical vapor condensation (CVC), thermal decomposition and reduction, and liquid phase reduction. - Surface modification of magnetic particles by polymers
We prevent agglomeration, cytotoxicity, and increased in vivo circulation by modifying magnetic nanoparticles with polymers that are biocompatible, have high affinity for metal oxides, and are non-immunogenic. We offer surface modification of magnetic particles with natural polymers (protein and polycarbonate) and synthetic organic polymers (polyethylene glycol, polyvinyl alcohol, poly-L-lactic acid, polyethylenimine). - Development of the magnectofection-based gene delivery system
We offer magnetofection technology to help our customers achieve rapid deposition of gene therapy agents into the target area and efficient transfection. We mix magnetic particles and nucleic acids together and apply external magnetic force to move the magnetic particles bound to the nucleic acids from the medium to the cell surface. In in vivo magnetofection, we focus the magnetic field on the target site to target the therapeutic gene to a specific organ or locus. - Fabrication of magnetic nanoparticles for nucleic acid delivery
We manufacture PEI-coated magnetic particles or magnetic nanoparticle-embedded polymeric micelles containing PEI for in vivo delivery of plasmid DNA. - Fabrication of magnetic nanoparticles for RNA delivery
We offer a variety of strategies for the synthesis of magnetic nanoparticles for siRNA and miRNA delivery. For example, we use PEI bound to iron oxide magnetic particles for efficient delivery of miRNA and attach siRNA to magnetic nanoparticles via disulphide bonds for efficient delivery of siRNA.
Our company focuses on a variety of nanoparticle surface modification methods to help our customers develop magnetic particles as effective gene vectors. If you need scientific services and technical support in the development of magnetic particle-based gene delivery vectors, please contact us for more details.
Reference
- Uthaman, S.; et al. Fabrication and development of magnetic particles for gene therapy. Polym. Nanomater. Gene Ther, 2016: 215-230.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
