Iron Metabolism-related Cancer Research Service
Iron is both an essential nutrient and potentially toxic, both of which play an important role in the development and progression of tumors. Protheragen offers a wide range of cancer research services related to iron metabolism to assist our clients with relevant drug development and pathology studies.
Iron Homeostasis and Cancer
Epidemiological studies have shown an association between excess iron and increased cancer incidence and risk, while experimental studies have shown an association between iron and cancer development, tumor growth, and metastasis. The role of iron in proliferation, metabolism and metastasis supports the association of iron with tumor growth and progression. Cancer cells exhibit an iron-seeking phenotype achieved through dysregulation of iron metabolism proteins. These changes are mediated, at least in part, by oncogenes and oncogenes.
Iron homeostasis and cancer[1].
Ferroptosis and Cancer
Ferroptosis: a non-apoptotic, iron-dependent regulatory cell death (RCD) that occurs when intracellular levels of lipid reactive oxygen species (L-ROS) exceed the antioxidant activity of glutathione-dependent peroxidase (GPX4), resulting in collapse of cellular redox homeostas is.
In recent years, an increasing number of studies has revealed the close relationships of ferroptosis with various human diseases, including Huntington's disease (HD), periventricular leukomalacia (PVL) and renal functional damage. A number of tumour cells, such as diffuse large B‐cell lymphoma (DLBCL), RCC, liver cancer, cervical carcinoma, osteosarcoma and prostate adenocarcinoma cells, are very susceptible to ferroptosis.
| Cancer Name | Ferroptosis Mechanism |
| Hepatocellular Carcinoma | The p62-Keap1-NRF2 pathway plays a key role in ferroptosis in hepatocellular carcinoma cells. p62 inhibits the degradation of NRF2 by disrupting Keap1, which leads to the accumulation of NRF2 in the cells. |
| Renal Cell Carcinoma | A study of the role of erastin in 60 tumor cell lines from 8 tissues found that RCC cells were more susceptible to erastin-induced cell death than other cells. |
| Pancreatic Carcinoma | Artesunate (ART) and erastin induce iron- and ROS-dependent cell death, respectively, in ductal pancreatic cancer. In particular, ductal pancreatic cancers with mutated KRas genes are more prone to ferroptosis. |
| Ovarian Cancer | ART induces iron and ROS-related cell death in ovarian cancer cells. |
Our Services
Protheragen has been working on iron metabolism related diseases for many years and has a complete protein assay platform and equipment to provide diverse iron metabolism related cancer research solutions according to the different needs of our clients. We will customize our technical solutions to meet the specific needs of our clients to solve all the problems found in their cancer research.
Iron Metabolism Detection in Cancer
Cancer cells employ a variety of mechanisms to increase iron bioavailability and thus promote tumor growth. We offer a wide range of iron metabolism assays and testing services to help our clients study the relationship and potential mechanisms of iron metabolism and tumorigenesis for drug development and therapy development.
- Serum Iron Determination
- Serum Ferritin Assay
- Total Iron Binding Capacity Determination
- Transferrin Saturation Assay
- Transferrin Determination
Ferroptosis Assay in Cancer
Ferroptosis is involved in a variety of tumorigenic processes. We provide services to detect ferroptosis in tumorigenesis by exogenous pathways or transporter-dependent pathways, and are committed to revealing the relationship and mechanisms between ferroptosis and various types of cancers to help our clients in drug and therapy development.
Why Choose US?
Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related diseases research services. If you have any needs, please contact us.
Reference
- Battaglia A M, et al. Ferroptosis and cancer: mitochondria meet the "iron maiden" cell death[J]. Cells, 2020, 9(6): 1505.