Iron Metabolism-related Protein Characterization Service

The importance of iron to almost all living organisms is undeniable. Iron is required for oxygen transport, energy production, DNA synthesis and cellular respiration. Over the past decade, several key mechanisms and proteins involved in iron regulation have been identified. with a high-end protein assay platform, Protheragen offers a wide range of iron metabolism protein assays including protein sequencing.

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Iron Metabolism-related Proteins

As an important trace element in the human body, iron is widely distributed in various body tissues and plays an important physiological role. For example, studies have shown that regional imbalances in brain iron metabolism are associated with many degenerative diseases of the central nervous system as well as cognitive and behavioral impairments in humans. The coordinated expression of proteins related to iron metabolism in organisms is important for the maintenance of iron homeostasis.

Systemic Iron Homeostasis^[1].

• Ferritin (Fn)
  Fn is a form of iron storage in which divalent iron taken up by tissue cells is oxidized to trivalent in the Fn shell and transferred to the iron nucleus, where it is stored in a non-toxic form.
• Transferrin (Tf) and Transferrin Receptor (TfR)
  Tf is a single peptide glycoprotein with a molecular weight of 80 kDa, containing two similar structural domains, each with a high-affinity Fe³⁺ binding site, and its main function is to transport iron between blood and tissues.
• Ceruloplasmin (Cp)
  Cp is a multi-copper oxidase with a molecular weight of 132 kDa, which is currently considered to have at least four functions: iron oxidation, copper transport, amine oxidation and antioxidant effect against free radical formation in serum.
• Ferroportin1 (FP1)
  FP1, also known as MTP1 (metal transporter protein 1), is an iron transporter protein found in small intestinal tissues that mediates the outward transport of Fe²⁺ in cells.
• Hepcidin (Hep)
  Hep is an iron-negative regulatory hormone mainly synthesized and secreted by the liver and is present in the small intestine, liver, bone marrow and among macrophages.

Intracellular iron homeostasis of a generic cell^[1].

Our Services

Protheragen has been dedicated to protein-related research for many years and has a complete protein assay platform and equipment to provide diversified protein assay solutions according to different needs of our customers. We will tailor our technical solutions to meet the specific needs of our customers to solve all their problems in iron metabolism related protein analysis.

Iron Metabolism-related Protein Structure Analysis

• Protein Primary Structure Analysis
  We provide mass spectrometry-based protein primary structure detection services, which include the determination of protein primary structure mainly including the determination of the number of polypeptide chains, the type, number, and order of amino acids in each polypeptide chain, and the position and number of disulfide bonds within or between polypeptide chains.
• Protein Circle Dichroism Analysis
  We provide professional circular dichroism services to resolve the secondary and tertiary conformations of proteins related to iron metabolism using circular dichroism. We help our clients to study the stereo structure, function, and interaction of target proteins.

Iron Metabolism-related Proteins Sequence Analysis

We offer a wide range of iron metabolism-related protein sequence analysis services, including mass spectrometry and non-mass spectrometry methods. We help our customers to analyze the structure and function of proteins.

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Features

Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related protein-based services. If you have any needs, please contact us.