Ferroptosis Analysis Services
Ferroptosis is defined as a form of iron-dependent regulated cell death caused by unrestricted lipid peroxidation and subsequent membrane damage, which can be triggered by extrinsic or intrinsic pathways.Ferroptosis can cause alterations in a wide range of physiological processes within cells, and Protheragen has experience in the field of cellular metabolism and provides our clients with imaging and assay services for Ferroptosis-related indicators and physiological processes.
Mechanism of Ferroptosis
Lipid peroxidation (the process of oxidative degradation of lipids by free radicals) is the main biochemical event that triggers ferroptosis. Therefore, dedicated enzymes to increase free radical production, fatty acid supply and lipid peroxidation are key to Ferroptosis.
- Free Radical Generation
by radicals, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are produced by iron-dependent Fenton reactions, mitochondria, or enzymes of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family. Excess ROS produced as a by-product of oxidative phosphorylation may cause oxidative damage to mitochondrial proteins, membranes, and DNA, thereby impairing mitochondrial function. - Fatty Acid Delivery
Lipid droplets can release fatty acids under stressful conditions to amplify lipid peroxidation during ferroptosis by activating autophagy. A low-fat diet may be a safe and beneficial strategy to prevent ferroptosis-related diseases. - Lipid Peroxidation
Lipid peroxidation is the most important cause of ferroptosis. Intracellular lipid oxidation metabolism is impaired and abnormal metabolism occurs under the catalytic effect of iron ions, and when the cellular antioxidant capacity is weakened, lipid reactive oxygen species accumulate, causing intracellular redox imbalance and inducing cell death.
Regulation of ferroptosis [1].
Our Services
Protheragen has been dedicated to cell morphology related research for many years and has a complete assay platform and imaging equipment to provide diverse solutions for cell morphology detection during ferroptosis according to the different needs of our customers. We will customize our technical solutions to meet the specific needs of our customers to solve all the problems found in their Ferroptosis studies.
Features
Advanced Technology
Experienced Team
High Quality and Efficiency
Best After-sales Service
Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related cellular assay services. If you have any needs, please contact us.
Reference
- Bogdan A R, et al. Regulators of iron homeostasis: new players in metabolism, cell death, and disease[J]. Trends in biochemical sciences, 2016, 41(3): 274-286.