Iron Metabolism Related Protein Expression Services
Iron is essential for life, but it can also lead to cell death. Therefore, cells have evolved a robust, tightly regulated set of proteins to maintain iron homeostasis. Protheragen provides recombinant protein expression services related to iron metabolism to help our customers perform in-depth studies of protein function.
Iron Metabolism-related Recombinant Protein Applications
Recombinant proteins are produced by applying the techniques of recombinant DNA or recombinant RNA thus obtaining proteins. The in vitro production of recombinant proteins is characterized by low cost and high efficiency, and is an important tool for iron metabolism research, which has a wide range of applications in various fields.
- Hepcidin (HEPC) Recombinant Protein As Therapeutics
Hepc, as an iron-negative regulatory hormone, can itself be an exogenous drug to lower the body's iron level for the treatment of iron overload diseases. Both domestic and foreign scholars have found that supplementation with exogenous Hepc has different degrees of efficacy in iron metabolism-related diseases such as hereditary hemochroma-tosis (HH), iron-related neurodegenerative diseases and chronic liver diseases with iron deposition. In addition, the development of a Hepc inhibitor or Hepc blocker would be useful for the treatment of diseases caused by chronic inflammatory anemia, such as chronic Hepc overexpression
Chemistry and Biology of Ferritin [1]. - Ferritin (HEPC) Recombinant Protein Used in Drug Delivery
Ferritin under artificial conditions is a cage-like structure with a central cavity structure, which can be loaded with drugs for drug encapsulation and delivery. Meanwhile, the ferritin shell can be genetically and chemically modified to increase targeting to achieve higher delivery efficiency. - Transferrin in Transferrin in Peroral Delivery
Transferrin has a promising future as a drug carrier in the field of oral delivery of protein peptide drugs. Transferrin can be used as a drug carrier for the absorption of peptide drugs in the intestine, and its delivery efficiency can be improved by appropriate modification of transferrin.
Our Services
Protheragen provides customizable protein expression technologies to provide customers with high-purity, low-cost iron metabolism-related recombinant proteins to meet their downstream scientific experimental research needs. We offer a wide range of in vitro protein expression methods, and customers can choose and customize our services according to their needs.
Customers can choose different nature protein tags according to the purpose of the experiment. Commonly used protein tags are 6xHis, Flag, GST, c-Myc, eGFP/eCFP/eYFP/mCherry, HA, SUMO, etc.
Protein Expression Systems
| Bacteria | Yeast | Insects | Mammals | |
| Prokaryotic Protein Expression | *** | * | * | * |
| Eukaryotic Protein Modification | No modifications | ** | ** | *** |
| Folding | * | ** | *** | *** |
| Glycosylation | - | * | ** | *** |
| Phosphorylation | - | * | ** | *** |
| Cycle Time | Short | Short | Long | Long |
| Cost | Low | Low | Medium | Medium |
| Recommended Application | Proproteins, standard proteins, functional proteins | Cytokines, small molecular weight proteins, enzymes | Glycosylated proteins, analytical experiments, secreted proteins | Functional applications, post-translational modifications, analytical experiments, property studies |
Our Advantages
Advanced Technology
Experienced Team
High Quality and Efficiency
Best After-sales Service
Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism protein expression services. If you have any needs, please contact us.
Reference
- Marina P, et al. Chemistry and biology of ferritin[J]. Metallomics, 2021(5):5.