Iron Metabolism-related Thalassemia Research Service
Thalassemia is a genetic disorder with multiple genetic forms, including alpha-thalassemia, beta-thalassemia, and hemoglobin E/beta-thalassemia. Protheragen offers a wide range of research services related to thalassemia to assist our clients with relevant drug development and pathology studies.
Thalassemia: A State of Ineffective Erythropoiesis and Iron Overload
- Types of Thalassemia
Iron overload is associated with increased morbidity in patients with transfusion-dependent thalassemia (TDT) and non-transfusion-dependent thalassemia (NTDT). Patients with NTDT do not require regular blood transfusions throughout their lives to survive. This type of thalassemia includes three clinically distinct forms: β-thalassemia, hemoglobin E/β-thalassemia, and α-thalassemia. In contrast, patients with TDT require regular, lifelong blood transfusions to survive.
Transfusion requirement in various thalassemia forms[1].
- Pathophysiology of TDT and NTDT Iron Overload
In TDT, iron accumulation in different organs leads to different clinical complications of iron overload. The metabolism of non-transferrin-bound iron generates reactive oxygen species leading to cellular dysfunction, apoptosis and necrosis in target organs. As NTDT has been increasingly examined and studied over the past few decades, it has been noted that iron overload differences in patients not dependent on regular red blood cell infusions involve the liver rather than the myocardium. iron overload in NTDT is associated with increased intestinal iron absorption driven by iron-regulator inhibition and erythrocyte expansion, and iron-regulator synthesized by the liver normally inhibits iron release from erythrocyte precursors, by binding to iron transport proteins that mediate iron export from hepatocytes, basolateral hepatocyte membranes, and macrophages.
Pathophysiology of β-thalassemia[2].
Our Services
Protheragen has been working on iron metabolism related diseases for many years and has a complete protein assay platform and equipment to provide diverse solutions for thalassemia research according to the different needs of our clients. We will customize our technical solutions to meet the specific needs of our customers to solve all the problems found in their research on this disease.
Thalassemia Animal Model Construction
Mouse models are the most commonly used models for disease research. With our high-end technology platform, we provide our customers with five types of mouse models of thalassemia to help researchers conduct disease-related research and drug development experiments.
Thalassemia Genetic Assay
We use a high-throughput sequencing platform to sequence and bioanalyze DNA samples from saliva samples, peripheral blood, etc. to confirm whether they carry the thalassemia gene, providing a test basis for disease research and drug development.
Iron Metabolism Detection in Thalassemia
We offer a wide range of iron metabolism assays and testing services to help our clients study the relationship and potential mechanisms of iron metabolism and thalassemia, laying the foundation for subsequent drug development and treatment.
- Serum Iron Level
- Serum GDF15 Levels
- Serum Hepcidin Levels
- Other Iron Metabolism Related Parameter
Why Choose US?
Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related diseases research services. If you have any needs, please contact us.
References
- Musallam K M, et al. Non-transfusion-dependent thalassemias[J]. haematologica, 2013, 98(6): 833.
- Mettananda S, et al. α-Globin as a molecular target in the treatment of β-thalassemia[J]. Blood, The Journal of the American Society of Hematology, 2015, 125(24): 3694-3701.