Iron Metabolism-related Protein Quantification Service

In vitro quantification of iron metabolism-related protein levels is used clinically as an aid in the diagnosis of diseases related to iron metabolism, such as hemochromatosis and iron deficiency anemia. Protheragen offers a variety of protein quantification assays to assist our customers in the analysis of iron metabolism-related proteins.

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Diseases Caused by Altered Levels of Iron Metabolism Proteins

Iron is an essential trace element in the human body, and the total iron content in a healthy adult is 3-5 g, of which 70% is heme iron, distributed in hemoglobin and myoglobin, and most of the rest is stored in hepatocytes and reticuloendothelial cells in the form of ferritin or iron-containing hemoglobin. To make up for this deficiency, the body is in a dynamic balance of iron absorption, utilization, storage, and circulation. Imbalance in iron homeostasis can lead to the development of iron metabolism-related diseases, including iron overload diseases and iron limitation diseases.

The Ferroportin–Hepcidin Axis Is Altered in Cancers^[1].

Iron Metabolism Related Diseases

Iron metabolism-related disorders are divided into two major categories: primary and secondary. Primary are disorders of iron metabolism caused by mutations in genes related to the regulation of iron metabolism, including hereditary hemochromatosis (HH) and iron-refractory iron deficiency anemia (IRIDA). Secondary are disorders of iron metabolism caused by secondary factors such as insufficient iron intake, inflammation, and erythropoietic activity, including iron deficiency anemia (IDA), inflammatory anemia (AI), thalassemia, and nephrogenic anemia.

Our Services

Protheragen has been dedicated to protein-related research for many years and has a complete protein assay platform and equipment to provide diverse protein quantification solutions according to the different needs of our customers. We will customize our technical solutions to meet the specific needs of our customers to solve all their problems in protein quantification related to iron metabolism.

iTRAQ/IBT/TMT Protein Quantification

We offer three quantitative proteomics services, iTRAQ/IBT/TMT, which can be used to screen and find differentially expressed proteins between samples caused by any factor, combined with bioinformatics to reveal cellular physiopathological functions, as well as qualitative and quantitative analysis of key proteins for iron metabolism.

FFPE Sample Protein Quantification

We offer differential proteomics studies based on FFPE samples, which can make full use of samples such as rare diseases or tumors to discover markers that are closely related to the diagnosis, staging, prognosis, and treatment of iron metabolism-related diseases.

Microsample Protein Quantification

We use in situ lysis to extract proteins, mass spectrometry data acquisition of protein enzymatic peptides by data dependent acquisition (DDA) mode, simultaneous construction of spectral libraries using proximate tissues or cells of the samples to be tested, and finally protein quantification of trace samples. This service is an important tool for studying protein content changes in iron metabolism at the single-cell level, helping customers to study iron metabolism-related diseases in greater depth.

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Features

Protheragen has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related protein-based services. If you have any needs, please contact us.