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AG-490
Product Name: | AG-490 |
CAT#: | DMME-2312-LGZ-3 |
Package: | 10mg/50mg/100mg/200mg/10mM * 1mL in DMSO |
Datasheet |
Description
AG 490 is a selective inhibitor of the EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). It also inhibits JAK2, but has no activity against Lck, Lyn, Btk, Syk, and Src.
Basic Information
Synonyms: | Tyrphostin AG490 |
Application: | EGFR Inhibitor |
CAS Number: | 133550-30-8 |
Formula: | C17H14N2O3 |
Molecular Weight: | 294.3 |
SMILES: | C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
Solubility-In vitro: | In vitro (25°C): DMSO: 54 mg/mL (183.48 mM) Water: Insoluble Ethanol: 6 mg/mL |
Solubility-In vivo: | 5% DMSO+40% PEG300+5% Tween80+50% ddH2O: 5.93 mg/mL |
Target Info
EGFR (Cell-free assay): | 0.1 μM |
JAK2 (Cell-free assay): | ~10 μM |
ErbB2 (Cell-free assay): | 13.5 μM |
Storage
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Preparing Stock Solutions
0.1 mM_1 mg: 33.98 mL
0.1 mM_5 mg: 169.89 mL
0.1 mM_10 mg: 339.79 mL
0.5 mM_1 mg: 6.8 mL
0.5 mM_5 mg: 33.98 mL
0.5 mM_10 mg: 67.96 mL
1 mM_1 mg: 3.4 mL
1 mM_5 mg: 16.99 mL
1 mM_10 mg: 33.98 mL
5 mM_1 mg: 0.68 mL
5 mM_5 mg: 3.4 mL
5 mM_10 mg: 6.8 mL
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