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Product Name: AG-490
CAT#: DMME-2312-LGZ-3
Package: 10mg/50mg/100mg/200mg/10mM * 1mL in DMSO


AG 490 is a selective inhibitor of the EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). It also inhibits JAK2, but has no activity against Lck, Lyn, Btk, Syk, and Src.

Basic Information

Synonyms: Tyrphostin AG490
Application: EGFR Inhibitor
CAS Number: 133550-30-8
Formula: C17H14N2O3
Molecular Weight: 294.3
SMILES: C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Solubility-In vitro: In vitro (25°C):
DMSO: 54 mg/mL (183.48 mM)
Water: Insoluble
Ethanol: 6 mg/mL
Solubility-In vivo: 5% DMSO+40% PEG300+5% Tween80+50% ddH2O: 5.93 mg/mL

Target Info

EGFR (Cell-free assay): 0.1 μM
JAK2 (Cell-free assay): ~10 μM
ErbB2 (Cell-free assay): 13.5 μM


  • The lyophilized form should be stored at -20°C, in a desiccated environment.
  • In lyophilized form, the chemical remains stable for 36 months.
  • In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 33.98 mL 0.1 mM_5 mg: 169.89 mL 0.1 mM_10 mg: 339.79 mL 0.5 mM_1 mg: 6.8 mL 0.5 mM_5 mg: 33.98 mL 0.5 mM_10 mg: 67.96 mL 1 mM_1 mg: 3.4 mL 1 mM_5 mg: 16.99 mL 1 mM_10 mg: 33.98 mL 5 mM_1 mg: 0.68 mL 5 mM_5 mg: 3.4 mL 5 mM_10 mg: 6.8 mL

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