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Animal Models for Ophthalmological Rare Diseases

Animal Models for Ophthalmological Rare Diseases

For rare ophthalmic diseases such as retinitis pigmentosa and non-infectious chronic uveitis, our company offers not only a variety of naturally occurring disease models but has also developed a series of eye-related gene editing models. These models have good phenotypic data and can be genetically stable and applied to various studies of ophthalmological rare diseases. Meanwhile, our professional and first-class analysis platform can provide the whole process of ophthalmic pharmacodynamic analysis including ocular injection administration, ocular biopsy, ocular tissue sampling, pathology analysis, and molecular testing of gene and protein expression.

Background

Ophthalmological rare diseases are mostly inherited blinding eye diseases that severely damage the structure and function of the eye and seriously affect the physical and mental health of patients and their offspring. Ophthalmic diseases designated as orphan conditions have heterogeneous causes, including inherited genetic defects (e.g., Leber's congenital claustrophobia (LCA) and Stargardt's disease), autoimmune syndromes, or neovascular damage.

In recent years, the underlying genetic factors of a range of ophthalmological rare diseases have been identified, and the development of relevant animal models has led to significant breakthroughs in preclinical research. The establishment and availability of stable and reliable animal models for ophthalmological rare diseases have incalculable potential for disease pathogenesis studies, drug target studies, and evaluation of therapeutic effects. Current orphan drug designations in this therapeutic area cover a wide range of therapeutic strategies, including gene therapy, peptides that induce immune tolerance, and neovascularization.

Fig. 1 Schemes of the eye structure, common ocular diseases, and ocular drug administration routes.

Fig. 1 Schemes of the eye structure, common ocular diseases, and ocular drug administration routes. (Nhàn N T T, et al., 2023)

Ophthalmological Rare Diseases Modeling Services

  • Animal Models for Ocular Autoimmune Diseases
    Non-infectious chronic uveitis and keratoconjunctivitis are two ocular autoimmune diseases designated as orphan diseases. We are committed to providing customized animal models for these two ocular autoimmune diseases and performing various tests and assays to evaluate potential treatments' efficacy.
    • Animal Models for Non-infectious Chronic Uveitis
    • Animal Models for Keratoconjunctivitis

Our Advantages

  • Multiple available animal models including mice, rats, dogs, canines, pigs, and non-human primates
  • Custom model development to meet specific client requirements
  • Professional animal model characterization
  • Extensive experience in preclinical research
  • Competitive pricing and fast turnaround time

Our company provides pre-clinical models and related services for pharmacology and toxicology. We maintain close communication and coordination with our clients during both model establishment and drug assessment. We aim to be the ideal research partner for understanding the pathogenesis of ophthalmological rare diseases in humans, identifying new therapeutic targets, and screening drugs. If you are interested in our animal modeling services, please contact us for more information.

Reference

  • Nhàn, N. T. T.; et al. Ocular delivery of therapeutic agents by cell-penetrating peptides. Cells, 2023, 12(7): 1071.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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