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Celiac Disease

Celiac disease, an autoimmune disorder impacting the small intestine, is commonly triggered by the consumption of gluten protein commonly found in wheat, barley, and rye. With a steadfast dedication to combating rare diseases like celiac disease, our company stands at the forefront of innovative strategies and technologies. By leveraging the expertise of our seasoned researchers and cutting-edge technologies, we can help you with novel insights and solutions in the realm of celiac disease research.

Introduction to Celiac Disease

Celiac disease is a multifaceted autoimmune condition. The disorder manifests when individuals with celiac disease consume gluten, triggering an abnormal immune response that directs attacks toward the lining of the small intestine. This heightened immune reaction leads to inflammation and harm to the fragile intestinal villi. Furthermore, celiac disease can result in a myriad of prolonged health issues including anemia, osteoporosis, infertility, and an elevated vulnerability to developing other autoimmune disorders.

Pathogenesis of Celiac Disease

Characterized as a hereditary disease, celiac disease arises from an allergy to gliadin, a component of gluten. In populations genetically predisposed to the condition, certain protein fragments within gluten activate T cells that are sensitive to gluten. This activation prompts an inflammatory cascade, culminating in the atrophy of intestinal villi, disrupting the absorption of essential nutrients within the small intestine and perpetuating the disease's progression (Fig.1).

Fig.1 Schematic representation of the proposed pathogenetic changes induced by gluten.Fig.1 Schematic representation of the proposed pathogenetic changes induced by gluten. (Giuffre, M., et al., 2022)

Therapeutics of Celiac Disease

Small Molecule Drugs Therapy

By inhibiting TG-2, ZED1227 effectively eliminates gluten-induced immune activation. PTG-100 (target integrin receptor α4β7) and vercinon ((target chemokine receptor 9) can interfere with lymphocyte transport and homing to the small intestine.

Vaccine Therapy

These vaccines aim to modulate the immune response to gluten, preventing the damage to the small intestine that occurs in individuals with celiac disease. Such as Nexvax-2 is a therapeutic vaccine, used to render these cells unresponsive to further antigen exposure.

Monoclonal Antibody Therapy

Monoclonal antibodies targeting specific cytokines like IL-15 (PRN15) or TNF-α (infliximab) have demonstrated success in modulating inflammatory responses and alleviating symptoms associated with gluten sensitivity.

Gene Therapy

Gene therapy to correct the underlying genetic causes of the disease or enhance the body's ability to tolerate gluten. Some research studies are exploring gene editing technologies like CRISPR-Cas9 to modify specific genes associated with celiac disease (such as HLA).

Our Services

By leveraging state-of-the-art technologies and tapping into the expertise of our team, we can support your research such as animal models and therapeutics platform development, and help you to illuminate the underlying mechanisms driving celiac disease and its associated complications.

Platforms of Celiac Disease Therapy Development

Animal Models of Celiac Disease 

These animal models play a crucial role in advancing knowledge of the disease and developing potential therapeutics for celiac disease. We can offer animal models such as spontaneous animal models, induced animal models, and transgenic models to help you research novel therapeutic targets and strategies to improve the diagnosis and therapeutics of celiac disease.

Diet-induced Models
The animal model of spontaneous celiac disease was constructed by directly feeding gluten protein. The modeling method was simple and in line with the actual situation of human exposure to gluten protein.
Optional Models
  • Glutenins model
  • Gliadin model
Chemical-induced Models
The induced animal model needs to be sensitized by gliadin, chemical or drug therapeutic, and genetic modification (such as intraperitoneal injection of IFN-γ or complete Freund's adjuvant) to induce the pathological characteristics of celiac disease.
Optional Models
  • IFN-γ model
  • Immunodeficiency model
Genetically Engineered Models
The transgenic animal model of celiac disease constructed by introducing human genes can more effectively simulate the characteristics of human celiac disease and can be used to evaluate the role of special genes in gluten protein sensitization, which helps elucidate the pathological mechanism of celiac disease.
Optional Models
  • HLA-DQ2/8 transgenic model
  • HLA-DQ8.Dd-IL-15Tg transgenic model
  • IL-15 transgenic model
Optional Species Mice, Rats, Others

We can offer different animal models to help you investigate the complex mechanisms involved in celiac disease development and progression. Which can support pharmacokinetics analysis and drug safety evaluation. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

References

  • Giuffre, Mauro, et al. "Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation." International journal of molecular sciences 23.24 (2022): 15564.
  • Machado, Mariana Verdelho "New Developments in Celiac Disease Treatment." International journal of molecular sciences 24.2 2023: 945.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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