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B-cell Lymphoid Proliferations and Lymphomas

Understanding the underlying mechanisms and heterogeneity of B-cell lymphoid proliferations and lymphomas is essential for the development of effective therapies. Our company, renowned for its expertise in biological solutions, is at the forefront of B-cell lymphoid proliferation and lymphoma drug and therapy development services.

Overview of B-cell Lymphoid Proliferations and Lymphomas

B-cell lymphoid proliferations and lymphomas encompass a group of malignancies that arise from B lymphocytes, a crucial component of the immune system. In recent years, extensive research has identified a multitude of targets for therapy development in B-cell lymphoid proliferations and lymphomas. CD20 antigen is one of the targets of this type of disease. Additionally, novel targets, including B-cell receptor (BCR) signaling pathways, Bcl-2 family members, and DNA damage response pathways, have emerged as potential avenues for therapeutic intervention.

Fig.1 Relationship between different definitions of splenic B-cell lymphoma entities.Fig.1 Relationship between different definitions of splenic B-cell lymphoma entities. (Alaggio, Rita, et al., 2022)

Classification of B-cell Lymphoid Proliferations and Lymphomas

Tumor-like lesions with B-cell predominance
Precursor B-cell neoplasms
B-lymphoblastic leukaemias/lymphomas
with iAMP21 with high hyperdiploidy with hypodiploidy
with ETV6::RUNX1-like features with BCR::ABL1 fusion   with ETV6::RUNX1 fusion
with TCF3::PBX1 fusion with IGH::IL3 fusion with TCF3::HLF fusion
with other defined genetic alterations with BCR::ABL1-like features with KMT2A rearrangement
Mature B-cell neoplasms
pre-neoplastic and neoplastic small lymphocytic proliferations
monoclonal B-cell lymphocytosis chronic lymphocytic leukemia / small lymphocytic lymphoma
splenic B-cell lymphomas and leukaemias
hairy cell leukemia splenic marginal zone lymphoma splenic diffuse red pulp small B-cell lymphoma
splenic B-cell lymphoma/leukemia with prominent nucleoli  
lymphoplasmacytic lymphoma
marginal zone lymphoma
pediatric nodal marginal zone lymphoma primary cutaneous marginal zone lymphoma nodal marginal zone lymphoma
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue  
follicular lymphoma
cutaneous follicle center lymphoma
mantle cell lymphoma
transformations of indolent B-cell lymphomas
large B-cell lymphomas
diffuse large B-cell lymphoma, NOS grey zone lymphoma
Burkitt lymphoma
KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
Hodgkin's lymphoma
classic Hodgkin lymphoma nodular lymphocyte predominant Hodgkin lymphoma  
Plasma cell neoplasms and other diseases with paraproteins
monoclonal gammopathies
diseases with monoclonal immunoglobulin deposition
heavy chain diseases
plasma cell myeloma / multiple myeloma

Therapy Development of B-cell Lymphoid Proliferations and Lymphomas


Chemotherapy has been a mainstay in B-cell lymphoid proliferations and lymphomas, particularly in aggressive subtypes. Combination regimens, such as CHOP (cyclophosphamide, vincristine, doxorubicin, and prednisone), have shown significant efficacy. However, the development of resistance and associated toxicities necessitates the exploration of alternative therapy options.


Immunotherapeutic approaches, including monoclonal antibodies and immune checkpoint inhibitors, have demonstrated remarkable success in B-cell lymphoid proliferations and lymphomas. These therapies harness the power of the immune system to target cancer cells specifically, while sparing normal cells.

Targeted Therapy

Targeted therapies that specifically inhibit abnormal signaling pathways implicated in B-cell lymphoid proliferations and lymphomas have emerged as a significant development in the field. Small molecule inhibitors, such as ibrutinib and idelalisib, have shown impressive efficacy in certain subtypes of B-cell Lymphoid Proliferations and Lymphomas by blocking key signaling molecules.

Our Services

Identification of reliable biomarkers is critical for accurate diagnostics and therapeutic development of B-cell lymphocyte proliferation and lymphoma. Our company utilizes cutting-edge technologies and analytical platforms to discover and validate biomarkers associated with disease progression. In addition, with our diverse therapy development platform, we are committed to driving the development of innovative B-cell lymphocyte proliferation and lymphoma therapies.

Our Therapy Development Platforms

Our company specializes in developing relevant and reliable animal models that recapitulate the complexities of B-cell lymphoid proliferations and lymphomas. In addition to these models, we also offer different animal species for evaluating drug efficacy, safety, and pharmacokinetics to enable informed decision-making during drug development. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.


  • Alaggio, Rita, et al. "The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms." Leukemia 36.7 (2022): 1720-1748.
  • Chadburn, Amy, Annunziata Gloghini, and Antonino Carbone. "Classification of B-Cell Lymphomas and Immunodeficiency-Related Lymphoproliferations: What's New?." Hemato 4.1 (2023): 26-41.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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