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Methotrexate (Abitrexate)
Product Name: | Methotrexate (Abitrexate) |
CAT#: | DMME-2312-LGZ-2 |
Package: | 100mg/200mg/500mg/10mM * 1mL in DMSO |
Datasheet |
Description
Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
Basic Information
Synonyms: | MTX; Amethopterin; Abitrexate; Rheumatrex; Trexall |
Application: | DHFR Inhibitor |
CAS Number: | 59-05-2 |
Formula: | C20H22N8O5 |
Molecular Weight: | 454.44 |
SMILES: | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O |
Solubility-In vitro: | In vitro (25°C): DMSO: Warmed: 89 mg/mL (195.84 mM) Water: Insoluble Ethanol: Insoluble |
Solubility-In vivo: | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 4 mg/mL |
Target Info
: | Traditional Cytotoxic Agents |
Storage
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Preparing Stock Solutions
0.1 mM_1 mg: 22.01 mL
0.1 mM_5 mg: 110.03 mL
0.1 mM_10 mg: 220.05 mL
0.5 mM_1 mg: 4.4 mL
0.5 mM_5 mg: 22.01 mL
0.5 mM_10 mg: 44.01 mL
1 mM_1 mg: 2.2 mL
1 mM_5 mg: 11 mL
1 mM_10 mg: 22.01 mL
5 mM_1 mg: 0.44 mL
5 mM_5 mg: 2.2 mL
5 mM_10 mg: 4.4 mL
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