Recombinant Human ADA Protein, N-His
Description
Adenosine Deaminase (ADA) is an important enzyme involved in breaking down purine nucleotides. It helps convert adenosine and deoxyadenosine into inosine and deoxyinosine through hydrolytic deamination. ADA is present in almost all tissues, with particularly high levels found in T-lymphocytes. Deficiency of ADA can lead to severe combined immunodeficiency (SCID) and lymphopenia affecting both B-cell and T-cell lineages. ADA serves as a useful diagnostic marker for tuberculous pleuritis. Despite being primarily located within cells, ADA also acts as a positive regulator of T-cell co-activation by binding to CD26 on the cell surface. This interaction between ADA and CD26 plays a role in regulating the adhesion between lymphocytes and epithelial cells.
Basic Information
| Synonyms: | ADA, ADA1, adenine deaminase, Adenosine aminohydrolase, Adenosine Deaminase, EC 3.5.4.4 |
| Source/Host: | E.coli |
| Tag: | N-His |
| Mol_Mass: | 29.59 kDa |
| AP_Mol_Mass: | 32 kDa |
| Uniprot: | P00813 |
| Accession: | P00813 |
| Sequence: | Lys11-Val280 |
| Species: | Human |
Product Properties
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Prior to lyophilization, add protectants including 5% - 8% trehalose, mannitol, and 0.01% Tween80. |
| Purity: | > 95 % (by reducing SDS-PAGE). |
Shipping and Handling
| Shipping: | Shipped with ice packs (the product is lyophilized powder). |
| Stability & Storage: | Please store lyophilized proteins at temperatures between -20 to -80°C for a maximum of 12 months. Once reconstituted, the protein solution can be stored at temperatures ranging from 4-8°C for a period of 2-7 days. If you need to store aliquots of reconstituted samples, please ensure they are kept below -20°C and they will remain stable for up to 3 months. |
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
