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Recombinant Human BRD4 Protein, N-10His-Flag
Description
BRD4 is a chromatin reader protein that plays a crucial role in transcriptional regulation and epigenetic memory. It binds to acetylated histones, maintains high-order chromatin structure, and promotes phosphorylation of RNA Polymerase II. Inhibitors targeting BRD4 show promise as therapeutic molecules for various diseases including leukemias and breast cancer.
Basic Information
| Synonyms: | HUNK1, HUNK1bromodomain-containing protein 4, HUNKI, MCAP |
| Source/Host: | E.coli |
| Tag: | N-10His-Flag |
| Mol_Mass: | 49 kDa |
| AP_Mol_Mass: | 55-60 kDa |
| Uniprot: | O60885 |
| Accession: | O60885 |
| Sequence: | Glu49-Glu460 |
| Species: | Human |
Product Properties
| Endotoxin Level: | < 1.0 EU per μg (LAL method). |
| Formulation: | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 200mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5. Prior to lyophilization, add protectants including 5% - 8% trehalose, mannitol, and 0.01% Tween80. |
| Purity: | > 95 % (by reducing SDS-PAGE). |
Shipping and Handling
| Shipping: | Shipped at refrigerated temperatures (the product is a liquid). |
| Stability & Storage: | Store the sample at a temperature below -20°C. It will remain stable for a period of 6 months. Please avoid subjecting it to repeated freeze-thaw cycles. |
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
