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Animal Models for Neovascular Glaucoma

Animal models have been a valuable tool in advancing the understanding of neovascular glaucoma (NVG) and in the development of new treatments. Our company offers a range of disease modeling services for NVG that enable researchers to study the disease in a controlled and reproducible manner. Our NVG animal models provide an excellent and valuable resource for researchers looking to advance their understanding of this serious ocular condition. With our expertise and state-of-the-art facilities, we are well-positioned to support a wide range of research projects aimed at developing new therapies and improving patient outcomes.

Background

NVG is a rare, aggressive, and blinding secondary glaucoma. Primary diseases include central venous obstruction (CRVO), diabetic retinopathy (DR), old retinal detachment, and ocular tumors. The typical clinical features are iris neovascularization and elevation of intraocular pressure (IOP). In recent years, there have been many experimental studies on NVG, and some new treatment methods have emerged. These therapies include pan-retinal photocoagulation (PRP), anti-VEGF therapy, drug therapy, and surgical treatment.

NVG formation is a dynamic process divided into three stages: pre-glaucoma, open-angle glaucoma, and angle-closure glaucoma. Without treatment, neovascularization of the iris (NVI) may further develop angle closure, resulting in elevated IOP and secondary NVG. At present, one of the difficulties in NVG research is the lack of ideal animal models, and the key to NVG models lies in the establishment of NVI models.

Fig. 1 Pictures describing NVG ophthalmic diagnostics.

Fig. 1 Pictures describing NVG ophthalmic diagnostics. (Urbonavičiūtė D, et al., 2019)

Disease Modeling Services

We are committed to providing our clients with the highest quality disease modeling services for NVG. We use state-of-the-art techniques to ensure animal models' reproducibility and validity, including rigorous quality control measures and standardized protocols. In addition, we offer a range of complementary services to support our clients' research, including histology, imaging, and molecular biology services.

We offer the following animal models:

  • Inflammation-induced angiogenesis in a surgical feline model. This surgical model involves lensectomy, vitrectomy, bipolar cauterization, and transection of the main branch veins in the cat's eye. These eyes develop to a clinical picture of NVI within 1-7 weeks.
  • Laser-induced choroidal neovascularization (CNV) model, which involves the use of a laser to induce the growth of blood vessels in the choroid layer of the eye. We applied laser retinal and/or CNV to rats, rabbits, and mice to achieve reproducible photocoagulation.
  • Novel mouse model. We performed uveal punctures on BALB/c mouse pups of any gender to stimulate NVI or injected ARPE-19 hypoxic conditioned medium to simulate NVG.
  • We also offer animal models of retinal vein occlusion-induced neovascularization and models of diabetic retinopathy-induced neovascularization, which allow researchers to study the effects of these underlying conditions on neovascularization in the eye.

Our team of experts has extensive experience in animal models and can provide customized study designs to meet our clients' specific needs. And our animal facilities are fully accredited and comply with all relevant regulations and guidelines. We are your preferred partner for studying NVG pathogenesis, identifying new treatment targets, and screening for new therapeutic drugs. If you are interested in our animal modeling services, please contact us for more information.

Reference

  • Urbonavičiūtė, D.; et al. A review of neovascular glaucoma: etiology, pathogenesis, diagnosis, and treatment. Medicina, 2022, 58(12): 1870.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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