CX-6258 HCl

Product Name:	CX-6258 HCl
CAT#:	DEP-2312-LGZ-7
Package:	5mg/10mg/25mg/10mM * 1mL in DMSO
Datasheet

Description

CX-6258 HCl is a highly effective, orally efficacious pan-Pim kinase inhibitor (IC50 values are 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3).

Basic Information

Synonyms:	CX6258
Application:	Pan-PIM kinase Inhibitor
CAS Number:	1353859-00-3
Formula:	C26H24ClN3O3.HCl
Molecular Weight:	498.4
SMILES:	CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl
*Solubility-In vitro:*	DMSO: Warmed: 55 mg/mL (110.35 mM) Water: Warmed: 86 mg/mL (172.55 mM) Ethanol: Warmed: 1 mg/mL (2 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

Pim1:	5 nM
Pim3:	16 nM
Pim2:	25 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 20.06 mL 0.1 mM_5 mg: 100.32 mL 0.1 mM_10 mg: 200.64 mL 0.5 mM_1 mg: 4.01 mL 0.5 mM_5 mg: 20.06 mL 0.5 mM_10 mg: 40.13 mL 1 mM_1 mg: 2.01 mL 1 mM_5 mg: 10.03 mL 1 mM_10 mg: 20.06 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 2.01 mL 5 mM_10 mg: 4.01 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.