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CX-6258 HCl

Product Name: CX-6258 HCl
CAT#: DEP-2312-LGZ-7
Package: 5mg/10mg/25mg/10mM * 1mL in DMSO


CX-6258 HCl is a highly effective, orally efficacious pan-Pim kinase inhibitor (IC50 values are 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3).

Basic Information

Synonyms: CX6258
Application: Pan-PIM kinase Inhibitor
CAS Number: 1353859-00-3
Formula: C26H24ClN3O3.HCl
Molecular Weight: 498.4
SMILES: CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)/C=C/4\C5=C(C=CC(=C5)Cl)NC4=O.Cl
Solubility-In vitro: DMSO: Warmed: 55 mg/mL (110.35 mM)
Water: Warmed: 86 mg/mL (172.55 mM)
Ethanol: Warmed: 1 mg/mL (2 mM)
* <1 mg/ml means slightly soluble or insoluble.

Target Info

Pim1: 5 nM
Pim3: 16 nM
Pim2: 25 nM


  • The lyophilized form should be stored at -20°C, in a desiccated environment.
  • In lyophilized form, the chemical remains stable for 36 months.
  • In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 20.06 mL 0.1 mM_5 mg: 100.32 mL 0.1 mM_10 mg: 200.64 mL 0.5 mM_1 mg: 4.01 mL 0.5 mM_5 mg: 20.06 mL 0.5 mM_10 mg: 40.13 mL 1 mM_1 mg: 2.01 mL 1 mM_5 mg: 10.03 mL 1 mM_10 mg: 20.06 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 2.01 mL 5 mM_10 mg: 4.01 mL

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