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Pim

Pim

Pim kinases are a family of serine/threonine protein kinases that play roles in cell development, immune regulation, and tumorigenesis. Early studies identified an oncogenic role of the Pim-1 family in lymphoma. Pim-2 has only 55% amino acid homology with Pim-1, but it is considered a compensatory protein of Pim-1 because it has a very similar kinase domain. Pim-3 catalyzes histone phosphorylation and autophosphorylation. All three Pim proteins can phosphorylate serine and threonine amino acids and activate similar cellular pathways.

Pim kinase is a key in tumor cell signal transduction. It promotes the occurrence and development of tumors by regulating cell cycle progression, accelerating transcription and translation, and inhibiting apoptosis. Highly efficient and low-toxic Pim kinase inhibitors are expected to become a new strategy for tumor treatment.

For more details about our Pim kinases, please click the links listed below.

  • (Z)-SMI-4a
  • CAT#:

    DEP-2312-LGZ-2

  • Application:

    Pim Inhibitor

  • CAS Number:

    327033-36-3

  • CX-6258
  • CAT#:

    DEP-2312-LGZ-4

  • Application:

    Pim Inhibitor

  • CAS Number:

    1202916-90-2

  • AZD1208
  • CAT#:

    DEP-2312-LGZ-5

  • Application:

    pan-Pim kinase Inhibitor

  • CAS Number:

    1204144-28-4

  • Hispidulin
  • CAT#:

    DEP-2312-LGZ-6

  • Application:

    Pim-1 Inhibitor

  • CAS Number:

    1447-88-7

  • CX-6258 HCl
  • CAT#:

    DEP-2312-LGZ-7

  • Application:

    Pan-PIM kinase Inhibitor

  • CAS Number:

    1353859-00-3

  • LGB-321 HCl
  • CAT#:

    DEP-2312-LGZ-8

  • Application:

    Pan-PIM kinase Inhibitor

  • CAS Number:

    1469925-36-7

  • PIM-1 Inhibitor 2
  • CAT#:

    DEP-2312-LGZ-10

  • Application:

    PIM-1 Inhibitor

  • CAS Number:

    477845-12-8

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