Pim

Pim kinases are a family of serine/threonine protein kinases that play roles in cell development, immune regulation, and tumorigenesis. Early studies identified an oncogenic role of the Pim-1 family in lymphoma. Pim-2 has only 55% amino acid homology with Pim-1, but it is considered a compensatory protein of Pim-1 because it has a very similar kinase domain. Pim-3 catalyzes histone phosphorylation and autophosphorylation. All three Pim proteins can phosphorylate serine and threonine amino acids and activate similar cellular pathways.

Pim kinase is a key in tumor cell signal transduction. It promotes the occurrence and development of tumors by regulating cell cycle progression, accelerating transcription and translation, and inhibiting apoptosis. Highly efficient and low-toxic Pim kinase inhibitors are expected to become a new strategy for tumor treatment.

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