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Nucleosides & Nucleotides

Nucleosides and Nucleotides

Nucleosides are glycosides formed from a pentose sugar and a base through a β-N glycosidic bond. Nucleosides and phosphates are linked by ester bonds to form nucleotides. Nucleotides are mainly involved in forming nucleic acids. Nucleotides in the human body are mainly synthesized by the body's cells themselves. Nucleotides are widely distributed in the body and mainly exist in the form of 5'-nucleotides in cells. Nucleotide compounds have important biological functions and are involved in almost all biochemical reactions in organisms.

Nucleotides are small organic molecules necessary for life activities. Abnormal synthesis and catabolism of purine nucleotides are the basis for certain diseases and are also targets for treatment. The occurrence and development of tumors involve a large number of pathophysiological processes, including imbalances in purine nucleotide metabolism. A variety of enzymes are involved in purine nucleotide synthesis and catabolism, which are related to the proliferation and drug resistance of tumor cells.

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