Peptide Synthesis

Peptide synthesis is generally synthesized from the C terminus (carboxyl terminus) to the N terminus (amino terminus). Peptide synthesis in solution is called liquid phase synthesis, which is a classic method of peptide synthesis. When designing compounds, short peptides should be selected as much as possible to improve their physiological activity and reduce clinical adverse reactions.

The synthesis of peptides is mainly divided into two pathways: chemical synthesis of peptides and biosynthesis of peptides. Chemical synthesis is mainly carried out in the form of condensation between amino acids. The biosynthetic methods of peptides mainly include fermentation and enzymatic hydrolysis. With the development of bioengineering technology, genetic engineering methods led by DNA recombinant technology have also been applied to the synthesis of peptides.

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