TCS PIM-1 4a (SMI-4a)

Product Name:	TCS PIM-1 4a (SMI-4a)
CAT#:	DEP-2312-LGZ-3
Package:	10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

TCS Pim-1 4a is a selective and ATP-competitive Pim kinase inhibitor with IC50 values of 24 and 100 nM for Pim-1 and Pim-2, respectively.

Basic Information

Application:	Pim Inhibitor
CAS Number:	438190-29-5
Formula:	C11H6F3NO2S
Molecular Weight:	273.23
SMILES:	O=C(NC/1=O)SC1=C\C2=CC=CC(C(F)(F)F)=C2
*Solubility-In vitro:*	In vitro (25°C): DMSO: 47 mg/mL (172.01 mM) Water: Insoluble Ethanol: 28 mg/mL (102.47 mM)
*Solubility-In vivo:*	30% PEG400+0.5% Tween80+5% propylene glycol: 28 mg/mL

Target Info

Pim1:

17 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 36.6 mL 0.1 mM_5 mg: 183 mL 0.1 mM_10 mg: 365.99 mL 0.5 mM_1 mg: 7.32 mL 0.5 mM_5 mg: 36.6 mL 0.5 mM_10 mg: 73.2 mL 1 mM_1 mg: 3.66 mL 1 mM_5 mg: 18.3 mL 1 mM_10 mg: 36.6 mL 5 mM_1 mg: 0.73 mL 5 mM_5 mg: 3.66 mL 5 mM_10 mg: 7.32 mL

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