The aryl hydrocarbon receptor (AhR) is a protein encoded by the AhR gene in humans. AhR proteins contain several domains that are critical for function and are classified as members of the bHLH/PAS family. AhR ligands are generally divided into two categories, synthetic or naturally occurring. The first ligands discovered were synthetic and included halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons.
AhR is a transcription factor that regulates gene expression and is widely expressed in immune, epithelial, endothelial, and stromal cells in barrier tissues. In addition to regulating metabolic enzymes, AhR also has functions in regulating immunity, stem cell maintenance, and cell differentiation.
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- StemRegenin 1 (SR1)