Norisoboldine

Product Name:	Norisoboldine
CAT#:	DMAR-2312-LGZ-4
Package:	10mg/25mg/50mg
Datasheet

Description

Norisoboldine, an alkaloid compound derived from Radix Linderae, exerts inhibitory effects on synovial angiogenesis in rats with adjuvant-induced arthritis. It achieves this by modulating the Notch1 pathway, specifically influencing the endothelial tip cell phenotype associated with angiogenesis.

Basic Information

Synonyms:	(+)-N-Norisoboldine; (+)-Laurelliptine; (S)-(+)-Laurelliptine
Application:	AhR Agonist
CAS Number:	23599-69-1
Formula:	C18H19NO4
Molecular Weight:	313.35
SMILES:	COC1=C(C2=C3C(CC4=CC(=C(C=C42)OC)O)NCCC3=C1)O
*Solubility-In vitro:*	DMSO: 56 mg/mL (178.71 mM) * <1 mg/ml means slightly soluble or insoluble.

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.91 mL 0.1 mM_5 mg: 159.57 mL 0.1 mM_10 mg: 319.13 mL 0.5 mM_1 mg: 6.38 mL 0.5 mM_5 mg: 31.91 mL 0.5 mM_10 mg: 63.83 mL 1 mM_1 mg: 3.19 mL 1 mM_5 mg: 15.96 mL 1 mM_10 mg: 31.91 mL 5 mM_1 mg: 0.64 mL 5 mM_5 mg: 3.19 mL 5 mM_10 mg: 6.38 mL

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