Epigenetic Reader Domain

Epigenetic regulators play a crucial role in controlling gene expression and modifying the chromatin state. These regulators can be categorized as "writers", "erasers", and "readers" of chromatin modifications. Readers are known for their specific domain interactions with modified chromatin. For instance, bromodomains are commonly associated with acetyllysine binding, while chromo, malignant brain tumor (MBT), plant homeodomain (PHD), and Tudor domains are often associated with methyllysine recognition.

The identification of selective inhibitors targeting bromodomains, such as the bromodomain and extra terminal motif (BET) family, has greatly advanced the field of epigenetic reader research. Notably, the human genome contains 46 proteins with a total of 61 bromodomains grouped into eight families.

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