Tenovin-6

Product Name:	Tenovin-6
CAT#:	DEERD-2312-LGZ-8
Package:	5mg/10mg/25mg/10mM * 1mL in DMSO
Datasheet

Description

Tenovin-6 is an analog of tenovin-1 that inhibits the protein deacetylase activity of purified human SIRT1, SIRT2 and SIRT3 in vitro. IC50 values are 21, 10 and 67 uM respectively.

Basic Information

Synonyms:	Tenovin6; Tenovin 6
Application:	p53 Activator
CAS Number:	1011557-82-6
Formula:	C25H34N4O2S
Molecular Weight:	454.6
SMILES:	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
*Solubility-In vitro:*	DMSO: 87 mg/mL (191.36 mM) Water: Warmed: 87 mg/mL (191.36 mM) Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

p53:	N/A
SIRT2:	10 μM
SIRT1:	21 μM
SIRT3:	67 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 22 mL 0.1 mM_5 mg: 109.99 mL 0.1 mM_10 mg: 219.97 mL 0.5 mM_1 mg: 4.4 mL 0.5 mM_5 mg: 22 mL 0.5 mM_10 mg: 43.99 mL 1 mM_1 mg: 2.2 mL 1 mM_5 mg: 11 mL 1 mM_10 mg: 22 mL 5 mM_1 mg: 0.44 mL 5 mM_5 mg: 2.2 mL 5 mM_10 mg: 4.4 mL

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